The patent's assignee for patent number 8529939 is
News editors obtained the following quote from the background information supplied by the inventors: "The localized and systemic delivery of pharmacologically active agents for treatment of body tissues, diseases, and wounds requires that for proper absorption of the particular pharmaceutical component, the drug delivery device be maintained at the site of administration for an effective period of time. Given the tendency of natural bodily fluids to clear applied pharmaceutical components from the site of administration, the administration of drugs to wet mucosal tissues located in body sites, such as buccal, sublingual, palate, nasal, vaginal, anal, urethral, stomach, intestinal or pulmonary areas, have been problematic. For example, in the mouth, saliva, natural replacement of the mucosal tissue, eating, drinking, and speaking movements are some of the problems that have limited the effectiveness and residence time of pharmaceutical carriers.
"Various benefits can be obtained through delivery of pharmacologically active agents through the mucosal tissue. For example, mucosal drug delivery is generally noninvasive, thereby avoiding the uncomfortable aspects of intravenous, intramuscular, or subcutaneous delivery means. Furthermore, mucosal drug delivery device attachment protects the pharmacologically active agents from clearance from the drug absorption site, thereby increasing the bioavailability of the drug.
"Many theories have been proposed to describe mucoadhesion, namely electronic theory, adsorption theory, wetting theory, diffusion theory and fracture theory. Mucoadhesion is believed to occur in three stages: wetting, interpenetration and mechanical interlocking between mucin and the mucoadhesive substance. According to electronic theory, mucoadhesion occurs from the formation of an electric double layer at the mucoadhesive interface by the transfer of electrons between the mucoadhesive substance and the mucin glycoprotein network. Adsorption theory states that mucoadhesive systems adhere to tissue through secondary molecular interactions such as
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