By a News Reporter-Staff News Editor at Computer Weekly News -- Fresh data on Drugs and Therapies are presented in a new report. According to news reporting from Trieste, Italy, by VerticalNews journalists, research stated, "The aim of the research was to investigate three 'critical steps' that deserve particular attention during the mechanochemical activation of vincamine. The first step consisted in the selection of the best polymeric carrier/most affine stabiliser between linear PVP and NaCMC by using the GRID and the GRID based AutoDock software packages which permit to calculate their surface features and interactions."
The news correspondents obtained a quote from the research from the University of Trieste, "Moreover, the calculation of the partial and total solubility parameters supported the results obtained by GRID and AutoDock software. Then, after the selection of linear PVP-K30 as the suitable carrier, the influence of process and formulation variables on the amorphisation degree and solubility enhancement was studied, to select the most suitable process conditions and formulation parameters. Subsequently, the best performing samples were widely characterised using XRPD, TEM and SSNMR (including the proton relaxation (H-1 T-1 NMR) time) techniques. These studies highlighted that all the coground samples were nanocrystalline solid dispersions indicating a dramatic difference between the amorphisation capacities of linear PVP-K30 and cross-linked PVP, used in previous analogous experiences. In particular, C-13, N-15 and H-1 T-1 NMR data point to a description of the system as a dispersion of nanocrystals in the polymer. In these dispersions vincamine is in a disordered crystalline state due to extensive interactions and contacts with PVP-K30 but the main hydrogen bonding motif characterising its packing remains. Again, differently from cross-linked PVP, dissolution studies revealed that linear PVP-K30 was able to promote a complete in vitro solubilisation of vincamine in some coground samples. What is more important, by using a linear polymer, drug-to-polymer and milling time variables appeared less influent on the solid state and in vitro properties of the composites."
According to the news reporters, the research concluded: "Finally, stability studies conducted for a period of I year highlighted the high physical stability of the selected samples."
For more information on this research see: Mechanochemical activation of vincamine mediated by linear polymers: Assessment of some "critical" steps. European Journal of Pharmaceutical Sciences, 2013;50(1):56-68. European Journal of Pharmaceutical Sciences can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutical Sciences - www.elsevier.com/wps/product/cws_home/523997)
Our news journalists report that additional information may be obtained by contacting D. Hasa, University of Trieste, Dept. of Geosci, I-34127 Trieste, Italy. Additional authors for this research include B. Perissutti, M. Grassi, M.R. Chierotti, R. Gobetto, V. Ferrario, D. Lenaz and D. Voinovich.
Keywords for this news article include: Italy, Europe, Trieste, Software, Drugs and Therapies
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