By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Bone Research are discussed in a new report. According to news reporting out of Iksan, South Korea, by NewsRx editors, research stated, "The purpose of this research was to characterize an Arg-Gly-Asp (RGD) peptide immobilized on TiO2 nanotubes. In addition, we investigated the effects of the RGD peptide-coated TiO2 nanotubes on the cellular response, proliferation, and functionality of osteogenic-induced human mesenchymal stem cells (hMSCs), which are osteoclasts that have been induced by bone marrow macrophages."
Our news journalists obtained a quote from the research from Wonkwang University, "The RGD peptide was grafted covalently onto the surface of TiO2 nanotubes based on the results of SEM, FT-IR, and XPS. Furthermore, the RGD peptide promoted the initial attachment and proliferation of the hMSCs, regardless of the size of the TiO2 nanotubes. However, the RGD peptide did not prominently affect the osteogenic functionality of the hMSCs because the peptide suppressed hMSC motility associated with osteogenic differentiation. The result of an in vitro osteoclast test showed that the RGD peptide accelerated the initial attachment of preosteoclasts and the formation of mature osteoclasts, which could resorb the bone matrix."
According to the news editors, the research concluded: "Therefore, we believe that an RGD coating on TiO2 nanotubes synthesized on Ti implants might not offer significant acceleration of bone formation in vivo because osteoblasts and osteoclasts reside in the same compartment."
For more information on this research see: Effect of RGD Peptide-Coated TiO2 Nanotubes on the Attachment, Proliferation, and Functionality of Bone-Related Cells. Journal of Nanomaterials, 2013;():1-11. Journal of Nanomaterials can be contacted at: Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 Pmb, New York, NY 10022, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nanomaterials - www.hindawi.com/journals/jnm/)
Our news journalists report that additional information may be obtained by contacting S. Oh, Wonkwang Univ, Coll Dental, Dept. of Oral Microbiol & Immunol, Iksan 570749, South Korea. Additional authors for this research include K.S. Moon and S.H. Lee (see also Bone Research).
Keywords for this news article include: Asia, Iksan, Nanotube, South Korea, Macrophages, Osteoclasts, Bone Research, Nanotechnology, Emerging Technologies
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