By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Bone Research have been presented. According to news reporting originating in Bethesda, Maryland, by NewsRx journalists, research stated, "The success of peripheral nerve regeneration is governed by the rate and quality of axon bridging and myelination that occurs across the damaged region. Neurite growth and the migration of Schwann cells is regulated by neurotrophic factors produced as the nerve regenerates, and these processes can be enhanced by mesenchymal stem cells (MSCs), which also produce neurotrophic factors and other factors that improve functional tissue regeneration."
The news reporters obtained a quote from the research from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, "Our laboratory has recently identified a population of mesenchymal progenitor cells (MPCs) that can be harvested from traumatized muscle tissue debrided and collected during orthopaedic reconstructive surgery. The objective of this study was to determine whether the traumatized muscle-derived MPCs exhibit neurotrophic function equivalent to that of bone marrow-derived MSCs. Similar gene-and protein-level expression of specific neurotrophic factors was observed for both cell types, and we localized neurogenic intracellular cell markers (brain-derived neurotrophic factor and nestin) to a subpopulation of both MPCs and MSCs. Furthermore, we demonstrated that the MPC-secreted factors were sufficient to enhance in vitro axon growth and cell migration in a chick embryonic dorsal root ganglia (DRG) model. Finally, DRGs in co-culture with the MPCs appeared to increase their neurotrophic function via soluble factor communication."
According to the news reporters, the research concluded: "Our findings suggest that the neurotrophic function of traumatized muscle-derived MPCs is substantially equivalent to that of the well-characterized population of bone marrow-derived MPCs, and suggest that the MPCs may be further developed as a cellular therapy to promote peripheral nerve regeneration."
For more information on this research see: Mesenchymal progenitor cells derived from traumatized muscle enhance neurite growth. Journal of Tissue Engineering and Regenerative Medicine, 2013;7(6):443-51. (Wiley-Blackwell - www.wiley.com/; Journal of Tissue Engineering and Regenerative Medicine - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1932-7005)
Our news correspondents report that additional information may be obtained by contacting W.M. Jackson, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Dept. of Health and Human Services, Bethesda, MD, United States. Additional authors for this research include P.G. Alexander, J.D. Bulken-Hoover, J.A. Vogler, Y. Ji, P. McKay, L.J. Nesti and R.S Tuan (see also Bone Research).
Keywords for this news article include: Biomedical Engineering, Biomedicine, Bethesda, Maryland, United States, Bone Research, Bioengineering, Tissue Regeneration, North and Central America.
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