By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Controlled Release. According to news reporting originating from Wuhan, People's Republic of China, by NewsRx correspondents, research stated, "Gallic acid (GA) is an interesting pharmaceutical component of plants. However, the short lifetime and the autoxidation of GA in aqueous solution significantly reduces its bioavailability and the residence time in the body system."
Our news editors obtained a quote from the research from the Huazhong University of Science and Technology, "In this study, GA was chemically bound to silica nanoparticles to control the release of GA based on the hydrolysis of the chemical bonds, and a silica nanoparticle drug delivery system was established. Gallic acid loaded silica nanoparticles (GA-SiO2) were synthesized by a modified Stober method. The Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Diffraction (XRD) analysis proved that GA did conjugate to silica nanoparticles. The particle size of the GA-SiO2 nanoparticles observed by Scanning Electron Microscope (SEM) was about 30 nm and the drug loading efficiency determined by Thermo Gravimetric Analysis/Differential Scanning Calorimetry (TGA/DSC) was 89.39%. The in vitro release study demonstrated that GA could be gradually released from the GA-SiO2. In addition, the antioxidant capability increased continuously during the immersion time, so the GA could serve as an excellent antioxidant to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a long release period."
According to the news editors, the research concluded: "Therefore, this study provided a novel drug delivery system for GA with controlled release capability and prolonged antioxidant activity."
For more information on this research see: Preparation, characterization and in vitro release study of gallic acid loaded silica nanoparticles for controlled release. Pharmazie, 2013;68(6):401-5. Pharmazie can be contacted at: Govi-Verlag GmbH, Pharmazeutischer Verlag Ginnheimer Strasse 26, D-65760 Eschborn, Germany. (Wiley-Blackwell - www.wiley.com/; Pharmazie - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1615-1003)
The news editors report that additional information may be obtained by contacting H. Hu, State Key Laboratory of Material Processing and Die & Mould Technology, Dept. of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, People's Taiwan. Additional authors for this research include L. Nie, S. Feng and J. Suo (see also Controlled Release).
Publisher contact information for the journal Pharmazie is: Govi-Verlag GmbH, Pharmazeutischer Verlag Ginnheimer Strasse 26, D-65760 Eschborn, Germany.
Keywords for this news article include: Asia, Antioxidants, Wuhan, Therapy, Gallic Acid, Nanoparticle, Nanotechnology, Carboxylic Acids, Organic Chemicals, Protective Agents, Controlled Release, Hydroxybenzoic Acids, Silicon Nanocrystals, Drug Delivery Systems, Emerging Technologies, People's Republic of China.
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