By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Proteins have been published. According to news reporting out of Kyoto, Japan, by NewsRx editors, research stated, "Hydrogel composites of oligo(poly(ethylene glycol) fumarate) (OPF) and gelatin microparticles (GMs) were investigated as carriers of bone morphogenetic protein-2 (BMP-2) for bone tissue engineering applications. Hydrogel composites with different physical characteristics were prepared by changing the amount and type (acidic vs. basic) of gelatin incorporated in the OPF bulk phase."
Our news journalists obtained a quote from the research from Kyoto University, "Composites with differing physical properties (degradation, swelling, and mechanical properties) and differing BMP-2 loading phase were investigated to determine the effect of these factors on BMP-2 release profiles over 28 days. Overall, higher gelatin amount increased the degradation and swelling of composites, and acidic GMs further increased the degradation and swelling and reduced the compressive modulus of the composites. The most significant factor affecting the release of BMP-2 from composites was the loading phase of the growth factor: GM loading reduced the burst release, increased BMP-2 release during the later phases of the experiment, and increased the cumulative release in faster degrading samples."
According to the news editors, the research concluded: "The results indicate that the physical properties and the BMP-2 release kinetics of hydrogel composites can be controlled by adjusting multiple parameters at the time of the hydrogel composite fabrication."
For more information on this research see: Bone Morphogenetic Protein-2 Release from Composite Hydrogels of Oligo(poly(ethylene glycol) fumarate) and Gelatin. Pharmaceutical Research, 2013;30(9):2332-2343. Pharmaceutical Research can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Pharmaceutical Research - www.springerlink.com/content/0724-8741/)
Our news journalists report that additional information may be obtained by contacting L.A. Kinard, Kyoto University, Dept. of Biomat, Kyoto, Japan. Additional authors for this research include C.Y. Chu, Y. Tabata, F.K. Kasper and A.G. Mikos (see also Proteins).
Keywords for this news article include: Asia, Tissue Engineering, Biomedical Engineering, Biomedicine, Kyoto, Japan, Alkenes, Gelatin, Alcohols, Hydrogel, Peptides, Fumarates, Bone Research, Bioengineering, Scleroproteins, Organic Chemicals, Dicarboxylic Acids, Polyethylene Glycols, Bone Morphogenetic Protein 2, TGF-beta Superfamily Proteins
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