By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Molecular Imaging are discussed in a new report. According to news reporting originating from Oak Ridge, Tennessee, by NewsRx correspondents, research stated, "We have developed a SPECT imaging system, AwakeSPECT, to enable molecular brain imaging of untrained mice that are conscious, unanesthetized, and unrestrained. We accomplished this with head tracking and motion correction techniques."
Our news editors obtained a quote from the research from Oak Ridge National Laboratory, "The capability of the system for motion-corrected imaging was demonstrated with a (99m)Tc-pertechnetate phantom, (99m)Tc-methylene diphosphonate bone imaging, and measurement of the binding potential of the dopamine transporter radioligand (123)I-ioflupane in mouse brain in the awake and anesthetized (isoflurane) states. Stress induced by imaging in the awake state was assessed through measurement of plasma corticosterone levels. AwakeSPECT provided high-resolution bone images reminiscent of those obtained from CT. The binding potential of (123)I-ioflupane in the awake state was on the order of 50% of that obtained with the animal under anesthesia, consistent with previous studies in nonhuman primates. Levels of stress induced were on the order of those seen in other behavioral tasks and imaging studies of awake animals."
According to the news editors, the research concluded: "These results demonstrate the feasibility of SPECT molecular brain imaging of mice in the conscious, unrestrained state and demonstrate the effects of isoflurane anesthesia on radiotracer uptake."
For more information on this research see: Molecular imaging of conscious, unrestrained mice with AwakeSPECT. Journal of Nuclear Medicine, 2013;54(6):969-76 (see also Molecular Imaging).
The news editors report that additional information may be obtained by contacting J.S. Baba, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States. Additional authors for this research include C.J. Endres, C.A. Foss, S. Nimmagadda, H. Jung, J.S. Goddard, S. Lee, J. McKisson, M.F. Smith, A.V. Stolin, A.G. Weisenberger and M.G Pomper.
Keywords for this news article include: Oak Ridge, Tennessee, United States, Nanotechnology, Molecular Imaging, Emerging Technologies, North and Central America.
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