By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Crystal Growth is now available. According to news reporting originating in Lancaster, United Kingdom, by NewsRx journalists, research stated, "Nanocrystals have the potential to address the challenges of delivering drugs with low aqueous solubility. In this study, the use of low energy anti-solvent precipitation for producing nanocrystals has been investigated."
The news reporters obtained a quote from the research from Lancaster University, "Stable nanocrystals with uniform particle size were prepared for the three model compounds, glyburide, ibuprofen, and artemisinin, which are all practically insoluble in water and have diverse molecular structures and crystal packings. The choice of crystal growth inhibitors/stabilizers was found to be critical and specific for each drug. The effect of the process variables, temperature, stirring rate, and the solute solution infusion rate into the antisolvent, was rationalized in terms of how these factors influence the local supersaturation attained at the earliest stages of precipitation. The dissolution of the nanocrystals in aqueous media under physiological conditions was shown in all cases to occur almost instantaneously, being markedly more rapid than that observed for micronized suspensions of the model drugs and their marketed tablet formulations. Rationalization of the choice of optimum stabilizers in terms of molecular interaction with the exposed crystal surfaces proved to be difficult."
According to the news reporters, the research concluded: "The study demonstrates that standard crystallization technology is effective in producing nanocrystals with the primary challenge being physicochemical (rather than mechanical), involving the identification of molecule specific crystal growth inhibitors and/or stabilizers."
For more information on this research see: Nanocrystal Preparation: Low-Energy Precipitation Method Revisited. Crystal Growth & Design, 2013;13(7):2766-2777. Crystal Growth & Design can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Crystal Growth & Design - www.pubs.acs.org/journal/cgdefu)
Our news correspondents report that additional information may be obtained by contacting S. Khan, University of Lancaster, Dept. of Chem, Lancaster LA1 4YB, United Kingdom. Additional authors for this research include M. de Matas, J.W. Zhang and J. Anwar (see also Crystal Growth).
Keywords for this news article include: Europe, Lancaster, Nanocrystal, United Kingdom, Crystal Growth, Nanotechnology, Emerging Technologies
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