"Electrochemical Biosensor Electrode Strip and a Fabrication Method Thereof Comprising a Titanium Metal Layer on a Carbon Layer as the Electrode Material" in Patent Application Approval Process
Patent application serial number 884337 has not been assigned to a company or institution.
The following quote was obtained by the news editors from the background information supplied by the inventors: "Recently, in the medicament field, an electrochemical biosensor has been frequently used to analyze biological samples including blood. Especially, an electrochemical biosensor using an enzyme is being widely used since its application is easy, it has high measurement sensitivity, and results can be quickly obtained.
"As to examples of such an electrochemical biosensor, there is a glucose measuring biosensor. The operation mechanism thereof will be described.
"As to a glucose measuring biosensor, a certain electrode is formed, and then a glucose oxidase, as an analysis reagent, is immobilized onto part of the electrode to form a reaction layer. When a blood sample is introduced onto the reaction layer, glucose in the blood is oxidized by the glucose oxidase, and the glucose oxidase is reduced. An electron acceptor oxidizes the glucose oxidase and is reduced. The reduced electron acceptor loses its electrons on the electrode surface, to which predetermined voltage has been applied, and is electrochemically re-oxidized. Since glucose concentration in the blood sample is in proportion to an amount of current generated during the oxidization of the electron acceptor, glucose concentration can be measured by measuring the current amount.
"By using this electrochemical biosensor, it is possible to measure uric acid and protein, in addition to glucose, in blood. Furthermore, it is possible to measure enzyme activity of GOT (Glutamate-Oxaloacetate Transaminase) or GPT (Glutamate-Pyruvate Transaminase) for DNA and liver function tests.
"Herein, the biosensor is divided into an identification portion for identifying an object to be measured and a conversion portion for performing conversion into an electrical signal. For the identification portion, a biological material is used, whereby when the biological material identifies an object to be measured, a chemical or physical change occurs. The conversion portion converts the change into an electrical signal and is generally called as a biosensor electrode.
"As to a method of fabricating this biosensor electrode, there is a silk printing method. A silk printing method is a printing method using platinum, carbon, or silver/silver chloride ink, which requires low equipment cost but has a problem since adjusting resistance variation to fabricate a sensor electrode requiring reproducibility is difficult.
"As to another method of fabricating the biosensor electrode, there is a vacuum deposition or sputtering method using a patterned mask and precious metals. According to this method, a patterned mask is deposited on a substrate, and vacuum deposition or sputtering using precious metals is performed to form electrode patterns. However, this method is problematic since costs are expensive due to use of precious metals, and there is difficulty in recovering precious metals.
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