However, documents obtained by a trade publication, The Cancer Letter, and the
The documents show that Chin, a member of the
The question of what DePinho knew about the drug before his
Aveo, which DePinho co-founded, disclosed in July of this year that the
During the 2012 television show, host Bartiromo asked DePinho what companies were doing the most promising work in cancer research.
After briefly mentioning one company with a past success, DePinho zeroed in on tivozanib. He called it "a very effective drug that has a superior safety profile for renal cell cancer," adding that it offered "massive advances" in treatment.
DePinho and his wife, Chin, held about 600,000 shares of Aveo stock at the time. The stock rose 12 percent in the week after DePinho's television appearance, to
But after the FDA rejected tivozanib Aveo's stock dropped significantly. It closed at
DePinho has previously acknowledged that his comments on
Chin's calendar shows she attended a
In a statement, Chin acknowledged attending the meeting, but said she could not disclose what was discussed because of confidentiality requirements. "I did not discuss the (scientific advisory board) meeting in question with Dr. DePinho," she said.
The clinical trial results showed that patients treated with tivozanib were less likely to survive a year later than patients who took the standard renal cell cancer drug. Nexavar.
Aveo officials were to meet with the
"The entire point of the meeting with the FDA is to go over safety and efficacy issues, known or otherwise," Patsner said. "Since the goal is to get FDA approval in order for a company to market a drug and make money, there is nothing to talk about other than the data. All of this had to be talked about at the scientific advisory board meeting."
Hired in 2011
When DePinho replaced Dr.
"He felt very strongly that he wanted to stay on the board until that first drug was approved by the FDA," Dr.
At the end of 2012 he stepped down from Aveo's board and a blind trust has recently been created to manage his assets.
And although both Chin and DePinho have very busy schedules, as their records indicate, the couple did spend some time together after she returned to
DePinho was one of four honorees that night.
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