By a News Reporter-Staff News Editor at Science Letter -- Data detailed on Nanoparticles have been presented. According to news originating from Stanford, California, by NewsRx correspondents, research stated, "Endoscopic imaging is an invaluable diagnostic tool allowing minimally invasive access to tissues deep within the body. It has played a key role in screening colon cancer and is credited with preventing deaths through the detection and removal of precancerous polyps."
Our news journalists obtained a quote from the research from Stanford University, "However, conventional white-light endoscopy offers physicians structural information without the biochemical information that would be advantageous for early detection and is essential for molecular typing. To address this unmet need, we have developed a unique accessory, noncontact, fiber optic-based Raman spectroscopy device that has the potential to provide real-time, multiplexed functional information during routine endoscopy. This device is ideally suited for detection of functionalized surface-enhanced Raman scattering (SERS) nanoparticles as molecular imaging contrast agents. This device was designed for insertion through a clinical endoscope and has the potential to detect and quantify the presence of a multiplexed panel of tumor-targeting SERS nanoparticles. Characterization of the Raman instrument was performed with SERS particles on excised human tissue samples, and it has shown unsurpassed sensitivity and multiplexing capabilities, detecting 326-fM concentrations of SERS nanoparticles and unmixing 10 variations of colocalized SERS nanoparticles. Another unique feature of our noncontact Raman endoscope is that it has been designed for efficient use over a wide range of working distances from 1 to 10 mm. This is necessary to accommodate for imperfect centering during endoscopy and the nonuniform surface topology of human tissue."
According to the news editors, the research concluded: "Using this endoscope as a key part of a multiplexed detection approach could allow endoscopists to distinguish between normal and precancerous tissues rapidly and to identify flat lesions that are otherwise missed."
For more information on this research see: A Raman-based endoscopic strategy for multiplexed molecular imaging. Proceedings of the National Academy of Sciences of the United States of America, 2013;110(25):E2288-E2297. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
The news correspondents report that additional information may be obtained from C.L. Zavaleta, Stanford University, Dept. of Mat Sci & Engn, Stanford, CA 94305, United States. Additional authors for this research include E. Garai, J.T.C. Liu, S. Sensarn, M.J. Mandella, D. Van de Sompel, S. Friedland, J. Van Dam, C.H. Contag and S.S. Gambhir (see also Nanoparticles).
Keywords for this news article include: Stanford, California, United States, Nanotechnology, Molecular Imaging, Emerging Technologies, North and Central America
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