By a News Reporter-Staff News Editor at Science Letter -- Fresh data on Materials Science and Physical Chemistry are presented in a new report. According to news reporting out of Changchun, People's Republic of China, by NewsRx editors, research stated, "Novel multifunctional poly(epsilon-caprolactone)-gelatin encapsulating upconversion core/shell silica nanoparticles (NPs) composite fibers as dual drugs delivery system (DDDS), with indomethacin (IMC) and doxorubicin (DOX) releasing in individual release properties, have been designed and fabricated via electrospinning process. Uniform and monodisperse upconversion (UC) luminescent NaYF4:Yb3+, Er3+ nanocrystals (UCNCs) were encapsulated with mesoporous silica shells, resulting in the formation of core/shell structured NaYF4:Yb3+, Er3+@mSiO(2) (UCNCs@mSiO(2)) NPs, which can be performed as DOX delivery carriers."
Our news journalists obtained a quote from the research from Jilin University, "These UCNCs@mSiO(2) NPs loading DOX then were dispersed into the mixture of poly(epsilon-caprolactone) (PCL) and gelatin-based electrospinning solution containing IMC, followed by the preparation of dual drug-loaded composite fibers (DDDS) via electrospinning method. The drugs release profiles of the DDDS were measured, and the results indicated that the IMC and DOX released from the electrospun composite fibers showed distinct properties. The IMC in the composite fibers presented a fast release manner, while DOX showed a sustained release behavior."
According to the news editors, the research concluded: "Moreover, the UC luminescent intensity ratios of H-2(11/2)/S-4(3/2)-I-4(15/2) to F-4(9/2)-I-4(15/2) from Er3+ vary with the amounts of DOX in the system, and thus drug release can be tracked and monitored by the luminescence resonance energy transfer (LRET) mechanism."
For more information on this research see: Electrospun Upconversion Composite Fibers as Dual Drugs Delivery System with Individual Release Properties. Langmuir, 2013;29(30):9473-9482. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
Our news journalists report that additional information may be obtained by contacting Z.Y. Hou, Jilin University, Coll Mat Sci & Engn, Minist Educ, Key Lab Automobile Mat, Changchun 130025, People's Republic of China. Additional authors for this research include X.J. Li, C.X. Li, Y.L. Dai, P.A. Ma, X. Zhang, X.J. Kang, Z.Y. Cheng and J. Lin (see also Materials Science and Physical Chemistry).
Keywords for this news article include: Asia, Changchun, People's Republic of China, Materials Science and Physical Chemistry
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