By a News Reporter-Staff News Editor at Science Letter -- Current study results on Nanoparticles have been published. According to news reporting out of Rochester, New York, by NewsRx editors, research stated, "Nanoparticle-mediated siRNA delivery is a complex process that requires transport across numerous extracellular and intracellular barriers. As such, the development of nanoparticles for efficient delivery would benefit from an understanding of how parameters associated with these barriers relate to the physicochemical properties of nanoparticles."
Our news journalists obtained a quote from the research from the University of Rochester, "Here, we use a multiparametric approach for the evaluation of lipid nanoparticles (LNPs) to identify relationships between structure, biological function, and biological activity. Our results indicate that evaluation of multiple parameters associated with barriers to delivery such as siRNA entrapment, pK(a), LNP stability, and cell uptake as a collective may serve as a useful prescreening tool for the advancement of LNPs in vivo. This multiparametric approach complements the use of in vitro efficacy results alone for prescreening and improves in vitro-in vivo translation by minimizing false negatives. For the LNPs used in this work, the evaluation of multiple parameters enabled the identification of LNP pK(a) as one of the key determinants of LNP function and activity both in vitro and in vivo."
According to the news editors, the research concluded: "It is anticipated that this type of analysis can aid in the identification of meaningful structure-function-activity relationships, improve the in vitro screening process of nanoparticles before in vivo use, and facilitate the future design of potent nanocarriers."
For more information on this research see: Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery. Proceedings of the National Academy of Sciences of the United States of America, 2013;110(32):12881-12886. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
Our news journalists report that additional information may be obtained by contacting C.A. Alabi, University of Rochester, Dept. of Biomed Engn, Rochester, NY 14627, United States. Additional authors for this research include K.T. Love, G. Sahay, H. Yin, K.M. Luly, R. Langer and D.G. Anderson (see also Nanoparticles).
Keywords for this news article include: New York, Rochester, United States, Nanotechnology, Emerging Technologies, North and Central America
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC