technology Group Describe New Findings in Lipopolysaccharides -->
By a News Reporter-Staff News Editor at Science Letter -- Current study results on Lipopolysaccharides have been published. According to news reporting originating from Kanagawa, Japan, by NewsRx correspondents, research stated, "The innate immune response is the earliest cellular response to infectious agents and mediates the interactions between microbes and cells. Toll-like receptors (TLRs) play an important role in these interactions."
Our news editors obtained a quote from the research from Biotechnology Group, "We have already shown that TLRs are involved with the uptake of titanium dioxide nanoparticles (TiO2 NPs) and promote inflammatory responses. In this paper, we compared role of cellular uptake and inflammatory response via TLR 4 to lipopolysaccharide (LPS) and TiO2 NPs. In the case of LPS, LPS binds to LPS binding protein (LBP) and CD 14, and then this complex binds to TLR 4. In the case of TiO2 NPs, the necessity of LBP and CD 14 to induce the inflammatory response and for uptake by cells was investigated using over-expression, antibody blocking, and siRNA knockdown experiments. Our results suggested that for cellular uptake of TiO2 NPs, TLR 4 did not form a complex with LBP and CD 14. In the TiO2 NP-mediated inflammatory response, TLR 4 acted as the signaling receptor without protein complex of LPS, LBP and CD 14. The results suggested that character of TiO2 NPs might be similar to the complex of LPS, LBP and CD 14."
According to the news editors, the research concluded: "These results are important for development of safer nanomaterials."
For more information on this research see: Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles. International Journal of Molecular Sciences, 2013;14(7):13154-13170. International Journal of Molecular Sciences can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland (see also Lipopolysaccharides).
The news editors report that additional information may be obtained by contacting S.S. Mano, TOTO Ltd Res Inst, Biotechnol Grp, Chigasaki, Kanagawa 2538577, Japan. Additional authors for this research include K. Kanehira and A. Taniguchi.
Keywords for this news article include: Asia, Japan, Kanagawa, Chemicals, Chemistry, Endotoxins, Immunology, Light Metals, Nanoparticle, Nanotechnology, Bacterial Toxins, Titanium Dioxide, Membrane Proteins, Lipopolysaccharides, Toll-Like Receptor 4, Emerging Technologies, Bacterial Polysaccharides, Pattern Recognition Receptors
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC