By a News Reporter-Staff News Editor at Science Letter -- Data detailed on Enzymes and Coenzymes have been presented. According to news reporting originating in Taejon, South Korea, by NewsRx journalists, research stated, "Glucokinase (GK) is a monomeric allosteric enzyme and plays a pivotal role in blood glucose homeostasis. GK is regulated by GK regulatory protein (GKRP), and indirectly by allosteric effectors of GKRP."
The news reporters obtained a quote from the research from the Graduate School of Nanoscience and Technology, "Despite the critical roles of GK and GKRP, the molecular basis for the allosteric regulation mechanism of GK by GKRP remains unclear. We determined the crystal structure of Xenopus GK and GKRP complex in the presence of fructose-6-phosphate at 2.9 angstrom. GKRP binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK. We demonstrate the molecular mechanism for the modulation of GK activity by allosteric effectors of GKRP. Importantly, GKRP releases GK in a sigmoidal manner in response to glucose concentration by restricting a structural rearrangement of the GK small domain via a single ion pair."
According to the news reporters, the research concluded: "We find that GKRP acts as an allosteric switch for GK in blood glucose control by the liver."
For more information on this research see: Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase. Proceedings of the National Academy of Sciences of the United States of America, 2013;110(25):10171-10176. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
Our news correspondents report that additional information may be obtained by contacting J.M. Choi, Korea Adv Inst Sci & Technol, Grad Sch Nanosci & Technol, Taejon 305701, South Korea. Additional authors for this research include M.H. Seo, H.H. Kyeong, E. Kim and H.S. Kim (see also Enzymes and Coenzymes).
Keywords for this news article include: Asia, Taejon, South Korea, Glucokinase, Enzymes and Coenzymes, Phosphotransferases (Alcohol Group Acceptor)
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