By a News Reporter-Staff News Editor at Journal of Engineering -- New research on Molecular Imaging is the subject of a report. According to news reporting from Xiamen, People's Republic of China, by VerticalNews journalists, research stated, "Simultaneous monitoring of the expression, distribution, and dynamics of biological molecules in living cells is one of the most challenging tasks in the analytical sciences. The key to effective and successful intracellular imaging is the development of delivery platforms with high efficiency and ultrasensitive molecular probes for specific targets of interest."
The news correspondents obtained a quote from the research from Xiamen University, "To achieve these goals, many nanomaterials are widely used as carriers to introduce nucleic acid probes into living cells for real-time imaging of biomolecules. However, limitations on their use include issues of cytotoxicity and delivery efficiency. Herein, we propose a switchable aptamer micelle flare (SAME), formed by self-assembly of an aptamer switch probe-diacyllipid chimera, to monitor ATP molecules inside living cells. Similarity of hydrophobic composition between diacyllipids in the micelle flares and phospholipid bilayers in the dynamic membranes of living cells allows SAMFs to be uptaken by living cells more efficiently than aptamer switch probes without external auxiliary. Switchable aptamers were found to bind target ATP molecules with high selectivity and specificity, resulting in restoration of the fluorescence signal from 'OFF' to 'ON' state, thus indicating the presence of the analyte."
According to the news reporters, the research concluded: "These switchable aptamer micelle flares, which exhibit cell permeability and nanoscale controllability, show exceptional promise for molecular imaging in bioanalysis, disease diagnosis, and drug delivery."
For more information on this research see: Engineering of Switchable Aptamer Micelle Flares for Molecular Imaging in Living Cells. ACS Nano, 2013;7(7):5724-5731. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news journalists report that additional information may be obtained by contacting C.C. Wu, Xiamen University, State Key Lab Phys Chem Solid Surface, Dept. of Biol Chem, Key Lab Analyt SciColl Chem & Chem Engn, Xiamen 361005, People's Republic of China. Additional authors for this research include T. Chen, D. Han, M.X. You, L. Peng, S. Cansiz, G.Z. Zhu, C.M. Li, X.L. Xiong, E. Jimenez, C.J. Yang and W.H. Tan.
Keywords for this news article include: Asia, Xiamen, Engineering, Nanotechnology, Molecular Imaging, Emerging Technologies, People's Republic of China
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