By a News Reporter-Staff News Editor at Journal of Engineering -- New research on Fullerenes is the subject of a report. According to news reporting from Chungli, Taiwan, by VerticalNews journalists, research stated, "Hydrogels have been developed as artificial extracellular matrixes (ECMs) to mimic native tissue microenvironments for various applications. Unfortunately, poly(N-isopropylacrylamide) (PNIPAAM)-based hydrogels are not suitable for cell culturing and cell sheet preparation."
The news correspondents obtained a quote from the research from Chung Yuan Christian University, "Carbon nanotubes (CNTs), with their mechanical strength and electrical conductivity, have been considered as additives to increase the applicability of hydrogels to cell encapsulation and advance cardiac electrophysiological functions. A simple method for fabrication of PNIPAAM hydrogels interpenetrated with multiwalled CNTs (MWCNTs) as substrates for cell sheet preparation is reported. The results demonstrate that PNIPAAM hydrogels with interpenetrating MWCNTs still exhibit thermosensitive behavior. It is also found that epithelial Madin-Darby canine kidney (MDCK) cells can only attach and proliferate on MWCNT-interpenetrated PNIPAAM hydrogels. Furthermore, the PNIPAAM hydrogels with MWCNTs possess higher elastic moduli and hydrophobicities than those without MWCNTs, suggesting these two characteristics are necessary for the cells to attach to the hydrogel surfaces. Moreover, cell sheets can only be harvested from PNIPAAM hydrogels with MWCNTs because of their high ratio of cell attachment."
According to the news reporters, the research concluded: "Thus, this simple method provides sufficient mechanical strength to PNIPAAM hydrogels so that anchorage-dependent cells can be cultivated and provides a superior system for preparing cell sheets."
For more information on this research see: Poly(N-isopropylacrylamide) hydrogels with interpenetrating multiwalled carbon nanotubes for cell sheet engineering. Biomaterials, 2013;34(30):7328-7334. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting Y.S. Chen, Chung Yuan Christian Univ, Dept. of Chem Engn, R&D Center Membrane Technol, Chungli 32023, Taiwan. Additional authors for this research include P.C. Tsou, J.M. Lo, H.C. Tsai, Y.Z. Wang and G.H. Hsiue.
Keywords for this news article include: Asia, Taiwan, Chungli, Fullerenes, Engineering, Nanotechnology, Carbon Nanotubes, Emerging Technologies
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