By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Silver Compounds. According to news reporting out of Daegu, South Korea, by NewsRx editors, research stated, "A rapid and sensitive chemiluminescence (CL) system coupled with a microfluidic chip has been presented to determine vitamin B12 (VB12) based on the reaction of luminol and silver nitrate (AgNO(3)) in the presence of gold nanoparticles (AuNPs). A microfluidic chip was fabricated by a soft-lithographic procedure using polydimethyl siloxane (PDMS) having four inlets and one outlet with a 200 ?m wide, 250 ?m deep, and 100 mm long microchannel."
Our news journalists obtained a quote from the research from Kyungpook National University, "Ag(+) was used as a chemiluminogenic oxidant in this CL reaction which oxidized luminol to produce strong CL signal in the presence of AuNPs. Luminol reacted with AgNO(3) under the catalysis of AuNPs to produce luminol radicals which reacted with dissolved oxygen and emitted CL light. The proposed CL system was applied to determine the amount of VB12 in VB12 tablets and multivitamin. Under the optimum conditions, the CL intensity of the system was increased with the concentration of VB12 in the range of 0.25-100 ng mL(-1) with the correlation coefficient of 0.9982. The limit of detection was found to be 0.04 ng mL(-1) with the relative standard deviation of 1.56 % for five replicate determinations of 25 ng mL(-1) of VB12."
According to the news editors, the research concluded: "The CL reaction mechanism was demonstrated by UV-visible spectra and CL emission spectra."
For more information on this research see: Chemiluminescence microfluidic system of gold nanoparticles enhanced luminol-silver nitrate for the determination of vitamin B12. Biomedical Microdevices, 2013;15(1):195-202. Biomedical Microdevices can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Biomedical Microdevices - www.springerlink.com/content/1387-2176/)
Our news journalists report that additional information may be obtained by contacting M. Kamruzzaman, Dept. of Chemistry, Kyungpook National University, Daegu, 702-701, South Korea. Additional authors for this research include A.M. Alam, K.M. Kim, S.H. Lee, Y.H. Kim, A.N. Kabir, G.M. Kim and T.D Dang (see also Silver Compounds).
Publisher contact information for the journal Biomedical Microdevices is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Asia, Daegu, Chemicals, Chemistry, South Korea, Nanoparticle, Nanotechnology, Silver Nitrate, Silver Compounds, Emerging Technologies.
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