By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Animal Diseases are discussed in a new report. According to news reporting originating from Columbus, Ohio, by NewsRx correspondents, research stated, "Porcine reproductive and respiratory syndrome (PRRS) is a chronic viral disease of pigs, has been posing a huge economic concern to pig industry worldwide. In this study, we developed biodegradable PLGA [poly(D,L-lactide-co-glycolide)] nanoparticle-entrapped killed PRRSV vaccine (Nano-KAg), and administered intranasally to pigs once and evaluated the immune correlates."
Our news editors obtained a quote from the research from Ohio State University, "In Nano-KAg vaccinated homologous virus challenged pigs, complete clearance of viremia was observed in 2 weeks, associated with a significant increase in virus neutralizing titers only in the lungs, compared to both unvaccinated and killed vaccine vaccinated pigs. The lung homogenate and sera of Nano-KAg vaccinated pigs had higher levels of IFN-gamma and lower levels of TGF-beta than control groups. Restimulation of mononuclear cells isolated from the lungs, blood, BAL, and TBLN of Nano-KAg vaccinated pigs' secreted significantly increased levels of Th1 cytokines, IFN-gamma and IL-12. In addition, higher frequencies of CD3(+)CD8(+), CD4(+)CD8(+), and gamma delta T cells, and reduced frequency of Foxp3(+) T-regulatory cells were observed in Nano-KAg vaccinated pigs."
According to the news editors, the research concluded: "Thus, intranasal delivery of Nano-KAg vaccine may be a suitable strategy to elicit anti-PRRSV immune response required to better clear viremia in pigs."
For more information on this research see: PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs. Veterinary Microbiology, 2013;166(1-2):47-58. Veterinary Microbiology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Veterinary Microbiology - www.elsevier.com/wps/product/cws_home/503320)
The news editors report that additional information may be obtained by contacting V. Dwivedi, Ohio State University, Dept. of Vet Prevent Med, Columbus, OH 43210, United States. Additional authors for this research include C. Manickam, B. Binjawadagi and G.J. Renukaradhya (see also Animal Diseases).
Keywords for this news article include: Ohio, Columbus, Virology, RNA Viruses, United States, Swine Diseases, Animal Diseases, Arterivirus Infections, Nidovirales Infections, North and Central America, Porcine Reproductive and Respiratory Syndrome
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