By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Bone Research have been presented. According to news reporting out of Rio de Janeiro, Brazil, by NewsRx editors, research stated, "Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term 'stem cell,' this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, potentially different therapeutic potential."
Our news journalists obtained a quote from the research from the National Institute of Traumatology, "Adherence to a culture flask surface is a primary defining characteristic of BMSCs. We hypothesized that based on the adherence time we could obtain an enriched population of cells with a greater therapeutic potential. We characterized two populations of bone marrow-derived cells, those that adhered by three days (R-cells) and those that did not adhere by three days but did by six days (L-cells). Clones derived from L-cells could be induced into adipogenic, chondrogenic, and osteogenic differentiation in vitro. L-cells appeared to have greater proliferative capacity, as manifested by larger colony diameter and clones with higher CD146 expression. Only clones from L-cells developed bone marrow stroma in vivo."
According to the news editors, the research concluded: "We conclude that the use of late adherence of BMSCs is one parameter that can be used to enrich for cells that will constitute a superior final product for cell therapy in orthopedics."
For more information on this research see: Late adherent human bone marrow stromal cells form bone and restore the hematopoietic microenvironment in vivo. Biomed Research International, 2013;2013():790842 (see also Bone Research).
Our news journalists report that additional information may be obtained by contacting V.F. Vianna, Clinical and Basic Research Division, National Institute of Traumatology and Orthopaedics, Avenida Brasil 500, 20940-070 Rio de Janeiro, RJ, Brazil. Additional authors for this research include D.C. Bonfim, A.DOSS. Cavalcanti, M.C. Fernandes, S.A. Kahn, P.L. Casado, I.C. Lima, S.S. Murray, E.J. Murray and M.E Duarte.
Keywords for this news article include: Brazil, Bone Marrow, South America, Bone Research, Immune System, Stromal Cells, Rio de Janeiro, Connective Tissue Cells.
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