By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Proteins are discussed in a new report. According to news reporting from Saitama, Japan, by NewsRx journalists, research stated, "Artificial beads including magnetite and fluorescence particles are useful to visualize pathologic tissue, such as cancers, from harmless types by magnetic resonance imaging (MRI) or fluorescence imaging. Desirable properties of diagnostic materials include high dispersion in body fluids, and the ability to target specific tissues."
The news correspondents obtained a quote from the research from Saitama Medical University, "Here we report on the development of novel magnetic nanoparticles (MNPs) intended for use as diagnosis and therapy that are coated with viral capsid protein VP1-pentamers of simian virus 40, which are monodispersive in body fluid by conjugating epidermal growth factor (EGF) to VP1. Critically, the coating of MNPs with VP1 facilitated stable dispersion of the MNPs in body fluids. In addition, EGF was conjugated to VP1 coating on MNPs (VP1-MNPs). EGF-conjugated VP1-MNPs were successfully used to target EGF receptor-expressing tumor cells in vitro."
According to the news reporters, the research concluded: "Thus, using viral Capsid protein VP1 as a coating material would be useful for medical diagnosis and therapy."
For more information on this research see: Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1. Journal of Biotechnology, 2013;167(1):8-15. Journal of Biotechnology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Biotechnology - www.elsevier.com/wps/product/cws_home/505515)
Our news journalists report that additional information may be obtained by contacting T. Enomoto, Saitama Med Univ, Dept. of Microbiol, Fac Med, Moroyama, Saitama 3500495, Japan. Additional authors for this research include M. Kawano, H. Fukuda, W. Sawada, T. Inoue, K.C. Haw, Y. Kita, S. Sakamoto, Y. Yamaguchi, T. Imai, M. Hatakeyama, S. Saito, A. Sandhu, M. Matsui, I. Aoki and H. Handa (see also Proteins).
Keywords for this news article include: Asia, Japan, Saitama, Therapy, Viruses, Virology, Nanoparticle, Nanotechnology, Viral Proteins, Emerging Technologies
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