Researchers Submit Patent Application, "Silicon Nanocarrier for Delivery of Drug, Pesticides and Herbicides , and for Waste Water Treatment", for Approval
No assignee for patent application serial number 406538 has been made.
News editors obtained the following quote from the background information supplied by the inventors: "The embodiments herein generally relate to a field of drug delivery systems and particularly to a drug delivery system using silicon nano vehicle or carrier and more particularly to a drug delivery system using diatoms as drug delivery vehicles or carriers.
"The desired loading and release properties for drug delivery could be achieved through a selection of appropriate systems and drug molecules. The designing of such new carriers for drug delivery is an important field of research. Nanotechnology as one of the new and latest fields of technology can help us to use naturally occurring structures in designing a new type of drug vehicles using diatoms. The diatoms are unicellular microalgae.
"Diatoms belong to Chrysophyta division, Bacillariophaceae class with a cell wall consisting of a siliceous skeleton or Frustule enveloped by an organic case essentially composed of polysaccharides and proteins. Diatoms as a group are very diverse in nature, comprising some 12,000-60,000 reported species and a common diameter of 20-200 microns. Diatoms are divided into two broad groups: centric and pinnate, depending on the symmetry of frustules. All diatoms have, parallel striates or furrows or rows of holes, in the silica arranged normal to the structural axis. The spacing between the adjacent striate is species specific, but typically varies from 0.3 to 2 .mu.m. The line of silica between the striate is called costae. Costae tend to be symmetrically arranged in combs or other space filling patterns.
"In the recent years some attempts have been made to use frustules in nanotechnology applications. Some researches in this field are as follows:
"Immuno-isolation and immunological bio-encapsulation could benefit from the frustule properties. The key feature of such capsules would be the ability of frustule pores to protect the enclosed tissue from immune rejection while allowing an adequate supply of nutrients and oxygen. One possible drawback could be the immune reactivity of the silica itself.
"Microfabrication: diatom frustules have potential use in the production of nanomaterials of constant diameter. For example, using a template synthesis method, it may be possible to arrange these pores to form nanometer sized tubes and/or fibers.
"Lithographic applications: using the costae of pinnate diatoms as a mask in the lithographic process led to the formation of parallel array of uniform channels. Use of centric diatoms, for which their exposed surface is resistant to the etching process, leads to a formation of radiating channels.
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