Researchers Submit Patent Application, "Blue-Colored Gold Nanoparticles for Immunological Measurement, Process for Production of Same, and Measurement Method Using Same", for Approval
No assignee for patent application serial number 883213 has been made.
News editors obtained the following quote from the background information supplied by the inventors: "In recent years, immunochromatographic strip type immunoassay has become more important as a simple in-vitro diagnostic kit or portable diagnostic device for detecting an antigen in a sample solution by making use of the specific reactivity which an antibody has. In particular, simple multiplex analysis tools based on immunochromatography for analyzing the presence or absence of infection with pathogens such as influenza virus or bacteria have been under research and development.
"Colloidal metal particles or latex particles have generally been used as an insoluble carrier to be used in an immunological measurement method. Latex particles need a cumbersome production step such as modification of a chemical functional group in order to firmly support a substance such as protein to be labeled. Therefore, colloidal gold particles capable of easily supporting a substance to be labeled and are produced conveniently at a low cost have been preferably used.
"Although immunochromatographic test drugs which have labeled an antibody with an insoluble carrier have been used generally since they are easy to operate and need only a short time for the test, a line which can be observed when the test result is positive is not clear since they have generally lower sensitivity in comparison with
"In order to overcome such a problem, various metal colloids having a higher sensitivity than conventional colloidal metal particles already put into practical use and are suitable as labeling agents for immunological measurement or protein staining agents are developed.
"Patent Document 1 provides colloidal metal particles having an average particle size of from 50 to 150 nm obtained by supporting platinum on the surface of colloidal metal particles (average particle size: from 30 to 100 nm) since colloidal platinum particles do not develop color sufficiently due to small average particle size and are not suited for practical use in immunochromatography. The colloidal metal particles are prepared by reducing chloroauric acid in a solvent to form colloidal gold particles and then reducing chloroplatinic acid in the presence of the resulting colloidal gold particles (refer to Patent Document 1).
"Patent Document 2 provides colloidal metal particles obtained by improving the above-mentioned colloidal metal particles and therefore having higher sensitivity. Namely, colloidal metal particles (average particle size: 30 to 100 nm) having platinum supported thereon which has an average particle size of 5 nm are provided. They are prepared in a production method wherein by adjusting, to a predetermined range, the amount of a reducing agent added in preparing colloidal metal particles in a medium and the amount of a reducing agent added in reducing and supporting platinum on the colloidal metal particles and wherein the medium does not substantially contain a protective colloid forming agent. Examples of such protective colloid forming agent include water soluble high-molecular substances such as PVA, PVP, and gelatin, surfactants, and high-molecular chelating agents (refer to Patent Document 2).
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