By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Nanoparticles have been published. According to news originating from Islamabad, Pakistan, by NewsRx correspondents, research stated, "Biological synthesis of nanoparticles is a growing innovative approach that is relatively cheaper and more environmentally friendly than current physicochemical processes. Among various microorganisms, fungi have been found to be comparatively more efficient in the synthesis of nanomaterials."
Our news journalists obtained a quote from the research from Quaid-I-Azam University, "In this research work, extracellular mycosynthesis of silver nanoparticles (AgNPs) was probed by reacting the precursor salt of silver nitrate (AgNO3) with culture filtrate of Aspergillus flavus. Initially, the mycosynthesis was regularly monitored by ultraviolet-visible spectroscopy, which showed AgNP peaks of around 400-470 nm. X-ray diffraction spectra revealed peaks of different intensities with respect to angle of diffractions (2 theta) corresponding to varying configurations of AgNPs. Transmission electron micrographs further confirmed the formation of AgNPs in size ranging from 5-30 nm. Combined and individual antibacterial activities of the five conventional antibiotics and AgNPs were investigated against eight different multidrug-resistant bacterial species using the Kirby-Bauer disk-diffusion method. The decreasing order of antibacterial activity (zone of inhibition in mm) of antibiotics, AgNPs, and their conjugates against bacterial group (average) was; ciprofloxacin + AgNPs (23). imipenem + AgNPs (21). gentamycin + AgNPs (19). vancomycin + AgNPs (16). AgNPs (15). imipenem (14). trimethoprim + AgNPs (14). ciprofloxacin (13). gentamycin (11). vancomycin (4). trimethoprim (0)."
According to the news editors, the research concluded: "Overall, the synergistic effect of antibiotics and nanoparticles resulted in a 0.2-7.0 (average, 2.8) fold-area increase in antibacterial activity, which clearly revealed that nanoparticles can be effectively used in combination with antibiotics in order to improve their efficacy against various pathogenic microbes."
For more information on this research see: Combined efficacy of biologically synthesized silver nanoparticles and different antibiotics against multidrug-resistant bacteria. International Journal of Nanomedicine, 2013;8():1-9. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Nanoparticles).
The news correspondents report that additional information may be obtained from S.Z.H. Naqvi, Quaid I Azam Univ, Fac Biol Sci, Dept. of Microbiol, Microbiol Res Lab, Islamabad 45320, Pakistan. Additional authors for this research include U. Kiran, M.I. Ali, A. Jamal, A. Hameed, S. Ahmed and N. Ali.
Keywords for this news article include: Asia, Pakistan, Islamabad, Nanotechnology, Emerging Technologies
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