By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- New research on Biotechnology is the subject of a report. According to news reporting from Sichuan, People's Republic of China, by NewsRx journalists, research stated, "This study investigated the expression pattern of PTEN and its effect on carcinogenesis of ulcerative colitis-associated colorectal cancer, leading to insights into the underlying molecular mechanism. We established a mouse model of ulcerative colitis-associated colorectal cancer by treating the animals with azoxymethane (AOM) and dextran sulphate sodium (DSS), and investigated the inflammation-dysplasia-carcinoma sequence."
The news correspondents obtained a quote from the research from Affiliated Hospital, "Expression patterns of PTEN, p-Akt and Ki-67 were shown by immunohistochemistry; western blotting techniques were used to detect protein expression of PTEN, p-Akt and caspase 3; TUNEL assay was used to measure apoptosis in colon epithelial cells; and colorimetric analysis was able to determine MPO activity in colon tissues. During the inflammation-dysplasia-carcinoma sequence, PTEN expression gradually decreased, while p-Akt expression increased; PTEN and p-Akt levels were negatively correlated. Compared to the AOM-DSS and Ad-0 groups, Ad-PTEN mice had longer colons, fewer tumours (P < 0.01) and smaller tumour sizes (P < 0.05). After injecting Ad-PTEN, expression of p-Akt, Ki-67 and MPO activity decreased dramatically, whereas PTEN increased. The TUNEL assay showed increased apoptotic cells and caspase 3 expression in the Ad-PTEN group."
According to the news reporters, the research concluded: "PTEN plays an important role in the inflammation-dysplasia-carcinoma sequence and may be a new molecular target in preventing and treating ulcerative colitis-associated colorectal cancer."
For more information on this research see: Effect of adenovirus-mediated PTEN gene on ulcerative colitis-associated colorectal cancer. International Journal of Colorectal Disease, 2013;28(8):1107-1115. International Journal of Colorectal Disease can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; International Journal of Colorectal Disease - www.springerlink.com/content/0179-1958/)
Our news journalists report that additional information may be obtained by contacting Z. Li, Lu Zhou Med College, Dept. of Gastroenterol, Affiliated Hosp TCM, Luzhou, Sichuan, People's Republic of China. Additional authors for this research include G.X. Liu, Y.L. Liu, X. Chen, X.L. Huang and H.T. Gan (see also technology.html">Biotechnology).
Keywords for this news article include: Biotechnology, Sichuan, Oncology, Carcinoma, Dysplasia, Colorectal, Dermatology, Colon Cancer, Inflammation, Gastroenteritis, Colonic Diseases, Gastroenterology, Ulcerative Colitis, Cancer Gene Therapy, Digestive System Diseases, Gastrointestinal Diseases, People's Republic of China
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