By a News Reporter-Staff News Editor at Women's Health Weekly -- Research findings on Oncology are discussed in a new report. According to news reporting originating in Providence, Rhode Island, by NewsRx journalists, research stated, "The aim of this study was to investigate the effects of poly-lactic-co-glycolic acid (PLGA) nanotopographies with alginate or chitosan protein preadsorption on the functioning of healthy and cancerous lung and breast cells, including adhesion, proliferation, apoptosis, and release of vascular endothelial growth factor (VEGF), which promotes tumor angiogenesis and secretion. We used a well established cast-mold technique to create nanoscale surface features on PLGA."
The news reporters obtained a quote from the research from the Department of Chemistry, "Some of the nanomodified PLGA films were then exposed to alginate and chitosan. Surface roughness and the presence of protein was confirmed by atomic force microscopy. Surface energy was quantified by contact angle measurement. Nanostructured PLGA surfaces with 23 nm features decreased synthesis of VEGF in both lung and breast cancer cells compared with conventional PLGA. Preadsorbing alginate further decreased cancer cell function, with nanostructured PLGA preadsorbed with alginate achieving the greatest decrease in synthesis of VEGF in both lung and breast cancer cells. In contrast, compared with nonmodified smooth PLGA, healthy cell functions were either not altered (ie, breast) or were enhanced (ie, lung) by use of nanostructured features and alginate or chitosan protein preadsorption. Using this technique, we developed surface nanometric roughness and modification of surface chemistry that could selectively decrease breast and lung cancer cell functioning without the need for chemotherapeutics."
According to the news reporters, the research concluded: "This technique requires further study in a wide range of anticancer and regenerative medicine applications."
For more information on this research see: Effects of chemically modified nanostructured PLGA on functioning of lung and breast cancer cells. International Journal of Nanomedicine, 2013;8():1907-19 (see also Oncology).
Our news correspondents report that additional information may be obtained by contacting L. Zhang, Dept. of Chemistry, Providence, RI, United States.
Keywords for this news article include: VEGF, Biomedical Engineering, Biomedicine, Oncology, Providence, Rhode Island, United States, Breast Cancer, Bioengineering, Women's Health, Protein Kinases, Membrane Proteins, Angiogenic Proteins, Phosphotransferases, Regenerative Medicine, Growth Factor Receptors, North and Central America.
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