By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Zinc Compounds. According to news reporting originating from Jinan, People's Republic of China, by NewsRx correspondents, research stated, "Zinc oxide nanoparticle is one of the most important materials with diverse applications. However, it has been reported that zinc oxide nanoparticles are toxic to organisms, and that oxidative stress is often hypothesized to be an important factor in cytotoxicity mediated by zinc oxide nanoparticles."
Our news editors obtained a quote from the research from the University of Shandong, "Nevertheless, the mechanism of toxicity of zinc oxide nanoparticles has not been completely understood. In this study, we investigated the cytotoxic effect of zinc oxide nanopartides and the possible molecular mechanism involved in calcium homeostasis mediated by plasma membrane calcium ATPase in rat retinal ganglion cells. Real-time cell electronic sensing assay showed that zinc oxide nanoparticles could exert cytotoxic effect on rat retinal ganglion cells in a concentration-dependent manner; flow cytometric analysis indicated that zinc oxide nanoparticles could lead to cell damage by inducing the overproduction of reactive oxygen species. Furthermore, zinc oxide nanoparticles could also apparently decrease the expression level and their activity of plasma membrane calcium ATPase, which finally disrupt the intracellular calcium homeostasis and result in cell death. Taken together, zinc oxide nanoparticles could apparently decrease the plasma membrane calcium ATPase expression, inhibit their activity, cause the elevated intracellular calcium ion level and disrupt the intracellular calcium homeostasis. Further, the disrupted calcium homeostasis will trigger mitochondrial dysfunction, generate excessive reactive oxygen species, and finally initiate cell death."
According to the news editors, the research concluded: "Thus, the disrupted calcium homeostasis is involved in the zinc oxide nanoparticle-induced rat retinal ganglion cell death."
For more information on this research see: Zinc oxide nanoparticles decrease the expression and activity of plasma membrane calcium ATPase, disrupt the intracellular calcium homeostasis in rat retinal ganglion cells. International Journal of Biochemistry & Cell Biology, 2013;45(8):1849-1859. International Journal of Biochemistry & Cell Biology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; International Journal of Biochemistry & Cell Biology - www.elsevier.com/wps/product/cws_home/395)
The news editors report that additional information may be obtained by contacting D.D. Guo, Shandong Univ Tradit Chinese Med, Jinan 250002, People's Republic of China. Additional authors for this research include H.S. Bi, D.G. Wang and Q.X. Wu (see also Zinc Compounds).
Keywords for this news article include: Asia, Jinan, Chemicals, Chemistry, Zinc Oxide, Nanoparticle, Nanotechnology, Zinc Compounds, Retinal Neurons, Emerging Technologies, Retinal Ganglion Cells, People's Republic of China
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