By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Pharmaceutical Science. According to news reporting originating in Frankfurt, Germany, by NewsRx journalists, research stated, "We investigated how the structure of nanofibers, resulting from interactions between anionic polyelectrolytes and cationic peptides, relies on the properties of the polyelectrolyte component. By using hyaluronate (H), carboxymethylcellulose (CMC), xanthan (X), and ozarelix (O), a cationic decapeptide, we determined the influence of characteristic polyelectrolyte parameters such as size and charge density on the formation of polyelectrolyte-peptide complexes."
The news reporters obtained a quote from the research from Pharmaceutical Development, "Transmission electron microscopy of unstained, frozen hydrated, or negatively stained samples revealed that the interaction between different anionic polyelectrolytes and ozarelix led to the formation of distinctly shaped nanofibers. CMC formed rather flexible structures with alternating thin and thick segments within the nanofibers with diameters ranging from 10 to 16nm and a length of up to 1m. Hyaluronate, a high-molecular-mass molecule, formed extra-long aggregates of more than 5m. Individual fibers with a diameter of 8nm aggregated to bigger strands. The nonlinear polysaccharide xanthan gum led to highly coiled structures. The diameter of the respective nanofibers varied between 15 and 25nm. Isothermal titration calorimetry was used to determine the binding constants and the thermodynamic parameters of the different polyelectrolyte-peptide complexes. The binding constant, which was of the order of 10(6) M-1, indicated a strong binding affinity, but also showed differences among the polyelectrolytes."
According to the news reporters, the research concluded: "These differences might be useful for prospective applications as drug delivery systems."
For more information on this research see: The impact of polyelectrolyte structure on the shape of nanoassemblies with cationic peptides. Journal of Pharmaceutical Sciences, 2013;102(8):2599-2607. Journal of Pharmaceutical Sciences can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Pharmaceutical Sciences - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6017)
Our news correspondents report that additional information may be obtained by contacting M. Ferstl, Aeterna Zentaris GmbH, Pharmaceut Dev, D-60314 Frankfurt, Germany. Additional authors for this research include M. Drechsler, R. Rachel, M. Rischer, J. Engel, M. Backofen and A. Goepferich (see also Pharmaceutical Science).
Keywords for this news article include: Pharmaceutical Science, Europe, Germany, Peptides, Proteins, Frankfurt, Amino Acids
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