By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news reporting from Singapore, Singapore, by NewsRx journalists, research stated, "Efforts to improve the clinical outcome of highly aggressive triple-negative breast cancer (TNBC) have been hindered by the lack of effective targeted therapies. Thus, it is important to identify the specific gene targets/pathways driving the invasive phenotype to develop more effective therapeutics."
The news correspondents obtained a quote from the research from Duke National University, "Here we show that ubiquitin-associated and SH3 domain-containing B (UBASH3B), a protein tyrosine phosphatase, is overexpressed in TNBC, where it supports malignant growth, invasion, and metastasis largely through modulating epidermal growth factor receptor (EGFR). We also show that UBASH3B is a functional target of anti-invasive microRNA200a (miR200a) that is down-regulated in TNBC. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity, which targets CBL ubiquitin ligase for dephosphorylation and inactivation, leading to EGFR up-regulation."
According to the news reporters, the research concluded: "Thus, UBASH3B may function as a crucial node in bridging multiple invasion-promoting pathways, thereby providing a potential therapeutic target for TNBC."
For more information on this research see: Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America, 2013;110(27):11121-11126. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
Our news journalists report that additional information may be obtained by contacting S.T. Lee, Duke Natl Univ Singapore, Grad Sch Med, Singapore 169857, Singapore. Additional authors for this research include M. Feng, Y. Wei, Z.M. Li, Y.Y. Qiao, P.Y. Guan, X. Jiang, C.H. Wong, K. Huynh, J.H. Wang, J.T. Li, K.M. Karuturi, E.Y. Tan, D.S.B. Hoon, Y.B. Kang and Q. Yu (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Oncology, Breast Cancer, Women's Health, Cancer Gene Therapy, Aromatic Amino Acids, Enzymes and Coenzymes, Protein Tyrosine Phosphatases, Phosphoric Monoester Hydrolases
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