By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Fresh data on Neurodegenerative Diseases are presented in a new report. According to news originating from Shenzhen, People's Republic of China, by NewsRx correspondents, research stated, "The treatment of Alzheimer's disease (AD) has been hampered by a lack of sensitive and specific non-invasive diagnostic methods. Quantum dots (QD) are nano-crystals with unique photo-physical properties that bypass some of the limitations of conventional dyes and imaging tools."
Our news journalists obtained a quote from the research from Peoples Hospital, "This study is aimed to evaluate the fluorescence properties of a QD probe conjugated with an anti-A beta antibody (QD-A beta-Ab). Healthy mice and mice bearing mutated human APP695swe and APP717 V-F transgenes received intracerebroventricular injection of the probe for subsequent imaging. Immunohistochemistry revealed that A beta(1-42) was distributed in the hippocampus CA1 area in the APP transgenic mice. Fluorescence microscopy demonstrated that fluorescence was mainly observed in the hippocampus area, the cerebral cortex, sagittal septum and striatum of APP transgenic mice. In vivo imaging of mice receiving the QD-A beta-Ab probe showed that healthy mice exhibited a narrow range of fluorescence and lower fluorescence intensity compared with APP transgenic mice. The mean fluorescence intensity of brain tissues of healthy C57BL mice was 12.3784 +/- A 3.9826, which was significantly lower than that of 10- and 16-month-old APP transgenic mice (45.03 +/- A 2.66 and 46.69 +/- A 3.22, respectively; P< 0.05)."
According to the news editors, the research concluded: "In this study we present the first direct evidence that QD-A beta-Ab conjugate probes can track in vivo state of A beta accumulation in mice and the findings suggest that such probes may be of potential use for early molecular diagnostic imaging of AD."
For more information on this research see: A Quantum Dot Probe Conjugated with A beta Antibody for Molecular Imaging of Alzheimer's Disease in a Mouse Model. Cellular and Molecular Neurobiology, 2013;33(6):759-765. Cellular and Molecular Neurobiology can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Cellular and Molecular Neurobiology - www.springerlink.com/content/0272-4340/)
The news correspondents report that additional information may be obtained from L. Feng, Nanshan Peoples Hosp, Dept. of Neurol, Shenzhen 518052, People's Republic of China. Additional authors for this research include H.Y. Long, R.K. Liu, D.N. Sun, C. Liu, L.L. Long, Y. Li, S. Chen and B. Xiao (see also Neurodegenerative Diseases).
Keywords for this news article include: Asia, Antibodies, Shenzhen, Dementia, Immunology, Tauopathies, Quantum Dots, Blood Proteins, Brain Diseases, Nanotechnology, Immunoglobulins, Alzheimer Disease, Molecular Imaging, Emerging Technologies, People's Republic of China, Neurodegenerative Diseases, Central Nervous System Diseases
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