By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news reporting originating in Seoul, South Korea, by NewsRx journalists, research stated, "Prostate cancer is the most common malignancy among men. Prostate cancer-related deaths are largely attributable to the development of hormone resistance in the tumor."
The news reporters obtained a quote from the research from the Chung Ang University College of Medicine, "No effective chemotherapy has yet been developed for advanced prostate cancer. It is desirable if a drug can be delivered directly and specifically to prostate cancer cells. Stem cells have selective migration ability toward cancer cells and therapeutic genes can be easily transduced into stem cells. In one form of gene therapy for cancer, the stem cells carry a gene encoding an enzyme that transforms an inert prodrug into a toxic product. Cytosine deaminase (CD) transforms the pro-drug 5-fluorocytosine into highly cytotoxic 5-fluorouracil (5-FU). The migration of the genetically modified stem cells was monitored by molecular magnetic resonance imaging, after labeling the stem cells with fluorescent magnetic nanoparticles (MNPs). Human neural stem cells encoding CD (HB1.F3.CD) were prepared and labeled with MNP. In tumor-bearing C57B mice, systemically transplanted HB1.F3.CD stem cells migrated toward the tumor and in combination with prodrug 5-FC, the volume of tumor implant was significantly reduced."
According to the news reporters, the research concluded: "These findings may contribute to development of a new selective chemotherapeutic strategy against prostate cancer."
For more information on this research see: Cytosine deaminase-expressing human neural stem cells inhibit tumor growth in prostate cancer-bearing mice. Cancer Letters, 2013;335(1):58-65. (Elsevier - www.elsevier.com; Cancer Letters - www.elsevier.com/wps/product/cws_home/506050)
Our news correspondents report that additional information may be obtained by contacting H.J. Lee, Medical Research Institute, Chung-Ang University College of Medicine, Seoul, South Korea. Additional authors for this research include S.W. Doo, D.H. Kim, Y.J. Cha, J.H. Kim, Y.S. Song and S.U Kim (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Seoul, Drugs, Genetics, Oncology, Proteins, Hydrolases, Proteomics, South Korea, Chemotherapy, Therapeutics, Prostate Cancer, Cytosine Deaminase, Stem Cell Research, Cancer Gene Therapy, Prostatic Neoplasms, Enzymes and Coenzymes, Nucleoside Deaminases.
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