The assignee for this patent, patent number 8524217, is
Reporters obtained the following quote from the background information supplied by the inventors: "Expression and cellular localization of MCP1 (CCL2), e.g., in MS has been described in the various locations including the CNS. Evidence has established a role for MCP1 in the recruitment of inflammatory infiltrate into the CNS. Hence, MCP1 may be a target for specific and effective treatment in multiple sclerosis (MS). Multiple sclerosis is an inflammatory demyelinating disease of the human central nervous system (CNS). In MS, CNS inflammation is associated with demyelination and axonal degeneration, which leads to clinical presentation.
"Exposure of circulating immune cells expressing the MCP1 receptor (CCR2) that typically mediate inflammatory diseases such as MS to continuously high circulating levels of MCP1 has been shown to desensitize such cells to the chemoattractant properties of the protein released from the tissue. For example, fusing the protein to an immunoglobulin so as to increase its half-life in the body of a subject has been shown to very effectively desensitize the cells (see US2007/0036750 A1)."
In addition to obtaining background information on this patent, NewsRx editors also obtained the inventors' summary information for this patent: "The present invention provides an isolated polypeptide comprising MCP1 fused to a polypeptide linker which is fused to a human immunoglobulin gamma-1 variant polypeptide comprising the immunoglobulin hinge to the immunoglobulin CH3 region; wherein the linker comprises an amino acid sequence set forth in a member selected from the group consisting of SEQ ID NOs: 1-13; e.g., comprising the amino acid sequence:
"TABLE-US-00001 (SEQ ID NO: 20) MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVI FKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT GGEPKSS DKTHTCPPCPAPELLGGPSVFLEPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVH NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYT LPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKS RWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK;
"or comprising the amino acid sequence:
"TABLE-US-00002 (SEQ ID NO: 16) QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKTGGEPKSSD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVAVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK.
"The present invention also provides an isolated polynucleotide (e.g., a cDNA) encoding any of said polypeptides; an isolated vector comprising the polynucleotide; an isolated host cell comprising the polynucleotide or a vector comprising said polynucleotide; e.g., wherein the host cell is a bacterial cell or a fungal cell, such as E. coli, Pichia or a Chinese hamster ovary cell. Also provided are compositions, e.g., pharmaceutical compositions, comprising any of said polypeptides or polynucleotides, and a carrier or buffer, e.g., a pharmaceutically acceptable carrier. Compositions comprising any of said polypeptides in association with one or more further therapeutic agents or a pharmaceutical composition thereof are also encompassed by the present invention; e.g., wherein the further therapeutic agent is a member selected from the group consisting of aspirin, diclofenac, diflunisal, etodolac, fenoprofen, floctafenine, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, phenylbutazone, piroxicam, salsalate, sulindac, tenoxicam, tiaprofenic acid, tolmetin, betamethasone benzoate, betamethasone valerate, clobetasol propionate, desoximetasone, fluocinolone acetonide, flurandrenolide, a topical steroid, alclometasone dipropionate, aloe vera, amcinonide, amcinonide, anthralin, betamethasone dipropionate, betamethasone valerate, calcipotriene, clobetasol propionate, coal tar,
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