No assignee for this patent application, patent application serial number 639519, has been made.
Reporters obtained the following quote from the background information supplied by the inventors: "Radiation therapy is a long-established and effective component of modern cancer therapy for localized disease. However, the ultimate utility of radiation therapy is limited by the fact that some cancer cells are resistant to ionizing radiation. Additionally, the delivery of the ionizing radiation through healthy tissue or beyond the tumor margin limits the radiation dose and may result in unwanted side effects. Attempts to improve outcomes of radiation therapy have largely focused on (i) increasing the dose of radiation delivered to the tumor while minimizing radiation to healthy tissue, (ii) sensitizing the radio-resistant fraction of tumor cells to conventional doses of radiation, and (iii) targeting cancer cells specifically while administering radiation therapy. The present invention uses nanotechnology-based techniques that combine these three approaches to improve radiation therapy outcomes for cancer. Nanoparticles comprised of high atomic weight (high-Z) elements are allowed to specifically accumulate in the target of radiation therapy, providing a localized dose enhancement as a result the interaction of the high atomic number (Z) element with the incident radiation. The selectivity of the nanoparticle for the target tissue allows the radiation dose to be enhanced at the target.
"Radiation Dose Enhancement Using High-Z Nanoparticles
"In recent years, intravenously administered nanoparticles (NPs) have shown great promise as anti-cancer agents. These NPs accumulate preferentially within tumors largely as a result of their size and passive extravasation from the leaky, chaotic and immature vasculature of tumors--a phenomenon referred to as the 'enhanced permeability and retention' (EPR) effect (Dvorak, et al. 1988; Unezaki, et al. 1996;
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