By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Immunology. According to news reporting originating from Albuquerque, New Mexico, by NewsRx correspondents, research stated, "Many membrane receptors are recruited to specific cell surface domains to form nanoscale clusters upon ligand activation. This step appears to be necessary to initiate cell signaling, including pathways in innate immune system activation."
Our news editors obtained a quote from the research from Sandia National Laboratories, "However, virulent pathogens such as Yersinia pestis (the causative agent of plague) are known to evade innate immune detection, in contrast to similar microbes (such as Escherichia coli) that elicit a robust response. This disparity has been partly attributed to the structure of lipopolysaccharides (LPS) on the bacterial cell wall, which are recognized by the innate immune receptor TLR4. It is hypothesized that nanoscale differences exist between the spatial clustering of TLR4 upon binding of LPS derived from Y. pestis and E. coli. Although optical imaging can provide exquisite details of the spatial organization of biomolecules, there is a mismatch between the scale at which receptor clustering occurs (400 nm). The last decade has seen the emergence of super-resolution imaging methods that effectively break the optical diffraction barrier to yield truly nanoscale information in intact biological samples. This study reports the first visualizations of TLR4 distributions on intact cells at image resolutions of
According to the news editors, the research concluded: "Importantly, it is also shown that LPS derived from immunostimulatory bacteria result in significantly higher LPS-TLR4 cluster sizes and a nearly twofold greater ligand/receptor colocalization as compared to immunoevading LPS."
For more information on this research see: Characterization of differential Toll-like receptor responses below the optical diffraction limit. Small, 2012;8(19):3041-9. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
The news editors report that additional information may be obtained by contacting J.S. Aaron, Sandia National Laboratories, PO Box 5800, MS-0895, Albuquerque, NM 87185, United States. Additional authors for this research include B.D. Carson and J.A Timlin (see also Immunology).
Keywords for this news article include: Nanoscale, New Mexico, Immunology, Albuquerque, United States, Nanotechnology, Membrane Proteins, Toll Like Receptors, Emerging Technologies, North and Central America, Pattern Recognition Receptors.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC