By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Research findings on Biotechnology are discussed in a new report. According to news reporting from Nanjing, People's Republic of China, by NewsRx journalists, research stated, "Estrogen receptor (ER) is a nuclear receptor and the insulin-like growth factor-I (IGF-I) receptor (IGF-IR) is a transmembrane tyrosine kinase receptor. Estrogen and IGF-I are known to have synergistic effects on the growth of breast cancer cells."
The news correspondents obtained a quote from the research from the Department of Medical Oncology, "Recently, non-nuclear effects of ER have been under investigation. To study the mechanism involved in this process, we have used MCF-7 breast cancer cell lines transfected with IGF-IR anti-sense cDNA (SX13, MCF-7(SX13)) that resulted in 50% reduction of IGF-IR. In MCF-7 cells, estradiol (E2) and IGF-I induced the rapid association of ER to IGF-IR, however, the interaction was abrogated in MCF-7(SX13) cells. In addition, NWTB3 cells (NIH3T3 cells overexpressing IGF-IR) were transiently transfected with ER?, the ER-IGF-IR interaction was induced by both E2 and IGF-I. Moreover, ER? regulated the IGF-I signaling pathways through phosphorylation of ERK1/2 and Akt and the interaction of ER-IGF-IR potentiated the cell growth. Finally, E2 and IGF-I stimulated translocation of ER from the nucleus to the cytoplasm."
According to the news reporters, the research concluded: "Taken together, these findings reveal that the interaction of the ER and IGF-IR is important for the non-genomic effects of ER."
For more information on this research see: Interaction between IGF-IR and ER Induced by E2 and IGF-I. Plos One, 2013;8(5):e62642. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news journalists report that additional information may be obtained by contacting Z. Yu, Dept. of Medical Oncology, Jinling Hospital, Nanjing, People's Taiwan. Additional authors for this research include W. Gao, E. Jiang, F. Lu, L. Zhang, Z. Shi, X. Wang, L. Chen and T. Lv (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Nanjing, Cancer Gene Therapy, People's Republic of China.
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