By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Data detailed on Biotechnology have been presented. According to news reporting originating in Chongqing, People's Republic of China, by NewsRx journalists, research stated, "Recent studies have elucidated the role of lysine-specific demethylase 1 (LSD1), a member of the histone demethylases, in epigenetic regulation of tumor suppressing/promoting genes and neoplastic growth. However, the expression of LSD1 in patients with esophageal squamous cell carcinoma (ESCC) is still unknown."
The news reporters obtained a quote from the research from Third Military Medical University, "Here, we reported that LSDI expression was elevated in cancerous tissue and correlated with lymph node metastasis and poorer overall survival in patients with ESCC. Compared to EC109 cells, LSD1 expression was unregulated in aggressive cancer cell lines KYSE450 and KYSE150. Knockdown of LSD1 using lentivirus delivery of LSD1-specific shRNA abrogated the migration and invasion of ESCC cells in vitro. Further, a LSD1 inhibitor, tranylcypromine, suppressed H3K4me2 demethylation and attenuated cellular motility and invasiveness in a dose-dependent manner."
According to the news reporters, the research concluded: "Taken together, these data suggested that LSD1 was a potential prognostic maker and may be a molecular target for inhibiting invasion and metastasis in ESCC."
For more information on this research see: High expression of lysine-specific demethylase 1 correlates with poor prognosis of patients with esophageal squamous cell carcinoma. Biochemical and Biophysical Research Communications, 2013;437(2):192-198. Biochemical and Biophysical Research Communications can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Biochemical and Biophysical Research Communications - www.elsevier.com/wps/product/cws_home/622790)
Our news correspondents report that additional information may be obtained by contacting Y.Y. Yu, Third Military Medical University, Daping Hosp, Inst Surg Res, Dept. of Pathol, Chongqing 400042, People's Republic of China. Additional authors for this research include B. Wang, K. Zhang, Z.J. Lei, Y. Guo, H.L. Xiao, J. Wang, L.L. Fan, C.H. Lan, Y.L. Wei, Q. Ma, L. Lin, C.Y. Mao, X. Yang, X.D. Chen, Y. Li, Y. Bai and D.F. Chen (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Lysine, Genetics, Oncology, Chongqing, Demethylase, Basic Amino Acids, Cancer Gene Therapy, Diamino Amino Acids, Enzymes and Coenzymes, Essential Amino Acids, Squamous Cell Carcinoma, People's Republic of China
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