By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators discuss new findings in Biotechnology. According to news originating from Tokyo, Japan, by NewsRx correspondents, research stated, "Distant metastasis is the major cause of cancer-related death in patients with colorectal cancer (CRC). Although the microRNA-200 (miR-200) family is a crucial inhibitor of epithelial-to-mesenchymal transition (EMT) in human cancer, the role of miR-200 members in the pathogenesis of metastatic CRC has not been investigated."
Our news journalists obtained a quote from the research from Toho University, "Fifty-four pairs of primary CRC and corresponding matched liver metastasis tissue specimens were analysed for expression and methylation status of the miR-200 family members. Functional analysis of miR-200c overexpression was investigated in CRC cell lines, and cells were analysed for proliferation, invasion and migration. Expression of several miR-200c target genes (ZEB1, ETS1 and FLT1) and EMT markers (E-cadherin and vimentin) in CRC cell lines and tissue specimens was validated. Liver metastasis tissues showed higher expression of miR-200c (primary CRC=1.31 vs. liver metastasis=1.59; p=0.0014) and miR-141 (primary CRC=0.14 vs. liver metastasis=0.17; p=0.0234) than did primary CRCs, which was significantly associated with hypomethylation of the promoter region of these miRNAs (primary CRC=61.2% vs. liver metastasis=46.7%; p
According to the news editors, the research concluded: "Its expression is epigenetically regulated, and miR-200c may serve as a potential diagnostic marker and therapeutic target for patients with CRC."
For more information on this research see: MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut, 2013;62(9):1315-1326. Gut can be contacted at: Bmj Publishing Group, British Med Assoc House, Tavistock Square, London WC1H 9JR, England. (BMJ Publishing Group - group.bmj.com/; Gut - gut.bmj.com/)
The news correspondents report that additional information may be obtained from K. Hur, Toho University, Fac Med, Dept. of Mol Biol, Ohta Ku, Tokyo, Japan. Additional authors for this research include Y. Toiyama, M. Takahashi, F. Balaguer, T. Nagasaka, J. Koike, H. Hemmi, M. Koi, C.R. Boland and A. Goel (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Tokyo, Japan, Genetics, Oncology, Colorectal, Hepatology, Colon Cancer, Therapeutics, Gastroenterology, Liver Metastasis, Cancer Gene Therapy
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