By a News Reporter-Staff News Editor at Stem Cell Week -- A new study on Stem Cell Research is now available. According to news reporting originating from Seoul, South Korea, by NewsRx correspondents, research stated, "Inspired by the aligned nanostructures and co-existence of vascular cells and stem cells in human cancellous bone, we quantitatively investigated the relative contributions of nanotopography and co-culture with human umbilical endothelial cells (HUVECs) to the osteogenesis of human mesenchymal stem cells (hMSCs). Although both nanotopography and co-culture independently enhanced the osteogenesis of hMSCs, osteogenesis was further enhanced by the two factors in combination, indicating the importance of synergistic cues in stem cell engineering."
Our news editors obtained a quote from the research from Seoul National University, "Interestingly, nanotopography provided a larger relative contribution to the osteogenesis of hMSCs than did co-culture with HUVECs. Furthermore, the osteogenesis of hMSCs was also affected by the density of parallel nanogrooves, exhibiting a maximum at a 1:3 spacing ratio, as defined as the ratio of ridge width to groove width."
According to the news editors, the research concluded: "Analysis of (i) biochemical soluble factors, (ii) hMSC-substrate interaction and (iii) hMSC-HUVEC interaction suggests that (ii) and (iii) play a crucial role in mediating osteogenic phenotypes."
For more information on this research see: Synergistic effects of nanotopography and co-culture with endothelial cells on osteogenesis of mesenchymal stem cells. Biomaterials, 2013;34(30):7257-7268. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news editors report that additional information may be obtained by contacting J. Kim, Seoul National University, Res Inst Agr & Life Sci, Seoul 151742, South Korea. Additional authors for this research include H.N. Kim, K.T. Lim, Y. Kim, S. Pandey, P. Garg, Y.H. Choung, P.H. Choung, K.Y. Suh and J.H. Chung (see also Stem Cell Research).
Keywords for this news article include: Asia, Seoul, South Korea, Nanotechnology, Nanotopography, Epithelial Cells, Endothelial Cells, Stem Cell Research, Emerging Technologies, Mesenchymal Stem Cells
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