By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Research findings on Biotechnology are discussed in a new report. According to news reporting from Naples, Italy, by NewsRx journalists, research stated, "Over the last decade, our knowledge of the multiple endocrine neoplasia (MEN) type 2 syndromes MEN2A and MEN2B and familial medullary thyroid carcinoma (FMTC) has expanded greatly. In this manuscript, we summarize how recent discoveries have enhanced our understanding of the molecular basis of these diseases and led to improvements in the diagnosis and management of affected patients."
The news correspondents obtained a quote from the research from the University of Naples Federico II, "Evidence Acquisition: We reviewed the English literature through PubMed from 2000 to the present, using the search terms medullary thyroid carcinoma, multiple endocrine neoplasia type 2, familial medullary thyroid carcinoma, RET proto-oncogene, and calcitonin. Evidence Synthesis: Over 70 RET mutations are known to cause MEN2A, MEN2B, or FMTC, and recent findings from studies of large kindreds with these syndromes have clouded the relationship between genotype and phenotype, primarily because of the varied clinical presentation of different families with the same RET mutation. This clinical variability has also confounded decisions about the timing of prophylactic thyroidectomy for MTC, the dominant endocrinopathy associated with these syndromes. A distinct advance has been the demonstration through phase II and phase III clinical trials that molecular targeted therapeutics are effective in the treatment of patients with locally advanced or metastatic MTC. The effective management of patients with MEN2A, MEN2A, and FMTC depends on an understanding of the variable behavior of disease expression in patients with a specific RET mutation."
According to the news reporters, the research concluded: "Information gained from molecular testing, biochemical analysis, and clinical evaluation is important in providing effective management of patients with either early or advanced-stage MTC."
For more information on this research see: Multiple Endocrine Neoplasia Type 2 and Familial Medullary Thyroid Carcinoma: An Update. Journal of Clinical Endocrinology & Metabolism, 2013;98(8):3149-3164. Journal of Clinical Endocrinology & Metabolism can be contacted at: Endocrine Soc, 8401 Connecticut Ave, Suite 900, Chevy Chase, MD 20815-5817, USA. (The Endocrine Society - www.endo-society.org/; Journal of Clinical Endocrinology & Metabolism - jcem.endojournals.org/)
Our news journalists report that additional information may be obtained by contacting S.A. Wells, University of Naples Federico II, Dipartimento Med Mol & Biotecnol Med, I-80131 Naples, Italy. Additional authors for this research include F. Pacini, B.G. Robinson and M. Santoro (see also technology.html">Biotechnology).
Keywords for this news article include: Biotechnology, Italy, Naples, Europe, Genetics, Oncology, Carcinoma, Endocrinology, Endocrine Research, Cancer Gene Therapy, Medullary Thyroid Cancer, Endocrine Gland Neoplasms, Endocrine System Diseases, Clinical Trials and Studies, Multiple Endocrine Neoplasia, Hereditary Neoplastic Syndromes
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