By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Nanoparticles. According to news reporting out of Lexington, Kentucky, by NewsRx editors, research stated, "PCBs bind to environmental particles; however, potential toxicity exhibited by such complexes is not well understood. The aim of the present study is to study the hypothesis that assembling onto nanoparticles can influence the PCB153-induced brain endothelial toxicity via interaction with the toll-like receptor 4 (TLR4)."
Our news journalists obtained a quote from the research from the University of Kentucky, "To address this hypothesis, TLR4-deficient and wild type control mice (males, 10 week old) were exposed to PCB153 (5 ng/g body weight) bound to chemically inert silica nanoparticles (PCB153-NPs), PCB153 alone, silica nanoparticles (NPs; diameter, 20 nm), or vehicle. Selected animals were also subjected to 40 min ischemia, followed by a 24 h reperfusion. As compared to exposure to PCB153 alone, treatment with PCB153-NP potentiated the brain infarct volume in control mice. Importantly, this effect was attenuated in TLR4-deficient mice. Similarly, PCB153-NP-induced proinflammatory responses and disruption of tight junction integrity were less pronounced in TLR4-deficient mice as compared to control animals. Additional in vitro experiments revealed that TLR4 mediates toxicity of PCB153-NP via recruitment of tumor necrosis factor-associated factor 6 (TRAF6)."
According to the news editors, the research concluded: "The results of current study indicate that binding to seemingly inert nanoparticles increase cerebrovascular toxicity of PCBs and suggest that targeting the TLR4/TRAF6 signaling may protect against these effects."
For more information on this research see: TLR4 signaling is involved in brain vascular toxicity of PCB153 bound to nanoparticles. Plos One, 2013;8(5):e63159. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news journalists report that additional information may be obtained by contacting B. Zhang, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, United States. Additional authors for this research include J.J. Choi, S.Y. Eum, S. Daunert and M. Toborek (see also Nanoparticles).
Keywords for this news article include: Kentucky, Lexington, United States, Nanotechnology, Emerging Technologies, North and Central America.
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