By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Peptide Proteins are presented in a new report. According to news reporting out of Tianjin, People's Republic of China, by NewsRx editors, research stated, "Nasal drug delivery system has been a very promising route for delivery of proteins and peptides for the reason that it can avoid degradation in gastrointestinal tract and metabolism by liver enzymes. However, the bioavailability of proteins and peptides is still low due to the rapid clearance of mucociliary."
Our news journalists obtained a quote from the research from Tianjin Medical University, "Here, to prolong the residence time of drugs and improve their absorption, we prepared amphiphilic glycopolymer poly(2-lactobionamidoethyl methacrylate-random-3-acrylamidophenylboronic acid) (p(LAMA-r-AAPBA), and the glycopolymer could assemble into the nanoparticles with narrow size distribution. Insulin, as a model drug, was efficiently encapsulated within the nanoparticles, and loading capacity was up to 12%. In vitro study revealed that the insulin release could be controlled by modifying the composition of glycopolymers. Cell viability showed that p(LAMA-r-AAPBA) nanoparticles had good cytocompatibility. Moreover, the mechanism of nanoparticle internalization into Calu-3 cells was a combination mechanism of clathrin-mediated endocytosis and lipid raft/caveolae-mediated endocytosis. Importantly, there was a significant decrease in the blood glucose levels after the nasal administration of p(LAMA-r-AAPBA) nanoparticles to diabetic rats."
According to the news editors, the research concluded: "Therefore, p(LAMA-r-AAPBA) glycopolymers have a potential application as a nasal delivery systems for proteins and peptides."
For more information on this research see: Amphiphilic glycopolymer nanoparticles as vehicles for nasal delivery of peptides and proteins. European Journal of Pharmaceutical Sciences, 2013;49(4):474-482. European Journal of Pharmaceutical Sciences can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutical Sciences - www.elsevier.com/wps/product/cws_home/523997)
Our news journalists report that additional information may be obtained by contacting C. Zheng, Tianjin Med Univ, Metab Dis Hosp, Key Lab Hormones & DevMinist Hlth, Collaborat Innovat Center Tianjin Med Epigenet 2011, Tianjin 300070, People's Republic of China. Additional authors for this research include Q.Q. Guo, Z.M. Wu, L. Sun, Z.P. Zhang, C.X. Li and X.G. Zhang (see also Peptide Proteins).
Keywords for this news article include: Asia, Tianjin, Amino Acids, Nanoparticle, Nanotechnology, Peptide Proteins, Emerging Technologies, People's Republic of China
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