By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on DNA Research is now available. According to news originating from Dortmund, Germany, by NewsRx correspondents, research stated, "Miniaturization is an important aspect of device fabrication. Despite the advancements of modern top-down approaches, scaling-down to the sub-nanometer size is still a challenge."
Our news journalists obtained a quote from the research from Technical University, "As an alternative, bottom-up approaches, such as the use of DNA as an engineering material, are therefore emerging, allowing control of matter at the single-molecule level. A DNA-based self-assembly method for the construction of switchable DNA devices is descrbied here based on G-quadruplex moieties, which are patterned on quasi-planar DNA arrays with nanoscale precision. The reversible switching of the devices is triggered by addition of DNA sequences ('fuels') and translated into linear extension/contractile movements. The conformational change of the devices was visualized by atomic force microscopy and FRET spectroscopy. Steady state fluorescence spectroscopy indicated that scaffolding of the G4 motors to either individual tiles or extended superlattices had no significant impact on the switching and optical performance of the system. However, time-resolved spectroscopy revealed that ordering in the microstructural environment enhances the fraction of molecules subject to FRET."
According to the news editors, the research concluded: "Altogether, our study confirms that DNA superstructures are well-suited scaffolds for accommodation of mechanically switchable units and thus opens the door to the development of more sophisticated nanomechanical devices."
For more information on this research see: Nanolattices of switchable DNA-based motors. Small, 2012;8(19):3000-8. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
The news correspondents report that additional information may be obtained from B. Sacca, TU Dortmund, Fakultat Chemie, Biologisch-Chemische Mikrostrukturtechnik, Otto-Hahn Str 6, D-44227 Dortmund, Germany. Additional authors for this research include B. Siebers, R. Meyer, M. Bayer and C.M Niemeyer (see also DNA Research).
Keywords for this news article include: Europe, Germany, Dortmund, DNA Research.
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