By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on Stem Cell Research. According to news reporting out of Dresden, Germany, by NewsRx editors, research stated, "Stem cells contribute to physiological processes such as postischemic neovascularization and vascular re-endothelialization, which help regenerate myocardial defects or repair vascular injury. However, therapeutic efficacy of stem cell transplantation is often limited by inefficient homing of systemically administered cells, which results in a low number of cells accumulating at sites of pathology."
Our news journalists obtained a quote from the research from the Leibniz Institute of Polymer Research Dresden, "In this study, anti-CD34 antibody-coated magnetic nanoparticles (Fe3O4@PEG-CD34) are shown to have high affinity to stem cells. The results of hemolysis rate and activated partial thromboplastin time (APTT) tests indicate that such nanoparticle may be used safely in the blood system. In vitro studies showed that a nanoparticle concentration of 100 mu g/mL gives rise to a significant increase in cell retention using an applicable permanent magnet, exerting minimal negative effect on cell viability and migration. Subsequent in vivo studies indicate that nanopartical can specifically bind stem cells with good magnetic response."
According to the news editors, the research concluded: "Anti-CD34 antibody coated magnetic nanoparticle may be used to help deliver stem cells to a lesion site in the body for better treatment."
For more information on this research see: Guidance of Stem Cells to a Target Destination in Vivo by Magnetic Nanoparticles in a Magnetic Field. ACS Applied Materials & Interfaces, 2013;5(13):5976-5985. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news journalists report that additional information may be obtained by contacting J.L. Chen, Max Bergmann Center Biomat Dresden, Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany. Additional authors for this research include N. Huang, B.L. Ma, M.F. Maitz, J. Wang, J.A. Li, Q.L. Li, Y.C. Zhao, K.Q. Xiong and X. Liu (see also Stem Cell Research).
Keywords for this news article include: Antibodies, Europe, Dresden, Germany, Immunology, Blood Proteins, Nanotechnology, Immunoglobulins, Stem Cell Research, Emerging Technologies, Magnetic Nanoparticles
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