By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Drugs and Therapies. According to news reporting from New Delhi, India, by NewsRx journalists, research stated, "The current antifilarial treatments are not up to the mark partly due to deep location of filarial parasites in the human lymphatic system. We report here on the improvement in the antifilarial activity of ivermectin (IVM) using chitosan-alginate nanoparticles prepared by modified complex coacervation method."
The news correspondents obtained a quote from the research from the All India Institute of Medical Sciences, "The nanoparticles were spherical having 155 nm size and 4.56 and 75.67 % loading and entrapment efficiency respectively for IVM. The delivery system maintained the sustained release and significantly augmented the microfilaricidal (MIF) activity at a single low dose (200 mu g/kg body weight, subcutaneously) in contrast to much higher dose of free ivermectin (400 mu g/kg body weight, subcutaneously) against human lymphatic filariid, Brugia malayi in rodent host, Mastomys coucha. To substantiate increase in MIF activity, pharmacokinetics study was designed on Wistar rats which revealed a greater peak plasma concentration (45.3 +/- 1.79 ng/ml), area under the concentration curve (298 +/- 38.7 ng d/ml) and extended mean residence time (23.4 +/- 8.56 days)of IVM in chitosan-alginate nanoparticles."
According to the news reporters, the research concluded: "Administration of 25 mg/kg of diethylcarbamazine following nanoparticle therapy significantly improved the MIF and macrofilaricidal action of encapsulated drug and was considered superior in this study."
For more information on this research see: Improved antifilarial activity of ivermectin in chitosan-alginate nanoparticles against human lymphatic filarial parasite, Brugia malayi. Parasitology Research, 2013;112(8):2933-2943. Parasitology Research can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Parasitology Research - www.springerlink.com/content/0932-0113/)
Our news journalists report that additional information may be obtained by contacting M. Ali, All India Inst Med Sci, Dept. of Pathol, New Delhi 110029, India. Additional authors for this research include M. Afzal, M. Verma, S. Misra-Bhattacharya, F.J. Ahmad and A.K. Dinda (see also Drugs and Therapies).
Keywords for this news article include: Asia, Antiinfectives, India, New Delhi, Ivermectin, Macrolides, Anthelmintics, Drugs and Therapies
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