By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Research findings on Diet and Nutrition Disorders are discussed in a new report. According to news reporting originating from Athens, Georgia, by NewsRx correspondents, research stated, "Adiponectin and its receptors are inversely related to the degree of obesity and have been identified as potential therapeutic targets for the treatment of obesity. In this study, we evaluated the effect of hydrodynamic delivery of adiponectin and/or its receptor 2 (adipoR2) genes on controlling the development of obesity and insulin resistance in AKR/J mice fed a high-fat diet."
Our news editors obtained a quote from the research from the University of Georgia, "An increase in adiponectin and adipoR2 gene expression by hydrodynamic gene delivery prevented diet-induced weight gain, reduced fat accumulation in liver and adipose tissue, and improved insulin sensitivity. Beneficial effects were seen with reduced gluconeogenesis in the liver and lipogenesis in the liver, white adipose tissue and skeletal muscle. Real-time PCR analysis demonstrated overexpression of adiponectin and adipoR2 significantly suppressed transcription of phosphoenolpyruvate carboxykinase (pepck), glucose-6-phosphatase (g6pase), stearoyl CoA desaturase 1 (scd-1) and fatty acid synthase (fas) gene. Inhibition effects were mediated by activating the AMP-activated protein kinase (AMPK)."
According to the news editors, the research concluded: "These results prove that elevation of adiponectin and/or adipoR2 expression via gene transfer is an effective approach in managing obesity epidemics."
For more information on this research see: Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet- induced obesity and insulin resistance. Gene Therapy, 2013;20(8):846-852. Gene Therapy can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Gene Therapy - www.nature.com/gt/)
The news editors report that additional information may be obtained by contacting Y. Ma, University of Georgia, Coll Pharm, Dept. of Pharmaceut & Biomed Sci, Athens, GA 30602, United States (see also Diet and Nutrition Disorders).
Keywords for this news article include: Biotechnology, Athens, Georgia, Obesity, Diabetes, Genetics, Bariatrics, Proinsulin, Gene Therapy, United States, Overnutrition, Bioengineering, Hyperinsulinism, Peptide Hormones, Membrane Proteins, Insulin Resistance, Adipokine Receptors, Adiponectin Receptors, North and Central America, Diet and Nutrition Disorders
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