Patent application serial number 883395 has not been assigned to a company or institution.
The following quote was obtained by the news editors from the background information supplied by the inventors: "User operated drug delivery devices are typically applicable in circumstances, where persons without formal medical training, in particular patients, need to administer an accurate and predefined dose of a medicament, such as heparin or insulin. Such devices are typically applied, where the medicament is to be administered on a regular or irregular basis of a short or long-term period.
"Generally, such devices should be robust in construction, jet easy to use in terms of handling and in understanding by the user of its operation and the delivery of the required dose. Furthermore, the dose setting must be easy and unambiguous. When the device is to be disposable rather than reusable, it should be inexpensive to manufacture and easy to dispose. To meet these requirements, the overall number of parts required to assemble the device should be kept on a minimum.
"The injectable medicament to be dispensed by way of such drug delivery devices is typically provided in a disposable or replaceable cartridge, such as a vial, ampoule or carpule comprising a barrel, typically of cylindrical geometry, and a piston slidably disposed therein for sealing the cartridge. While a proximal end of the cartridge is provided with the piston to be operably engaged with a piston rod of the drug delivery device's drive mechanism, opposite, at its distal end section, the cartridge is typically sealed by a sealing member which is to be pierced by a piercing element, like an injection needle or cannula in order to establish a fluid transferring coupling allowing to dispense the medicament.
"This way, by applying thrust to the cartridge's piston in distal direction, a pre-defined dose of the liquid medicament can be dispensed and expelled from the cartridge in a well-defined way.
"The distal sealing member, commonly denoted as septum is typically designed as a rubber stopper providing an air-tight seal to be pierced and penetrated by the piercing element.
"In order to provide an air-tight but pierceable seal, the septum is made of a flexible and mechanically deformable material. In the course of dose dispensing, a respective fluid pressure in the inner volume of the cartridge is built-up, which, due to the elastic properties of the septum may lead to a respective expansion or elastic deformation of the septum. Consequently, the septum may expand into or even through an aperture provided in a fixing cap which in turn is intended to keep the septum in its sealing position at the distal end of the cartridge.
"By such pressure induced expansion, prolongation or general deformation, the distally located sealing member inevitably stores elastic energy during a dose dispensing procedure. Typically, when after termination of the dose dispensing procedure the fluid pressure inside the cartridge returns to an initial and lower value, the sealing member relaxes into its initial shape. This relaxation process is typically accompanied by a retraction of the previously expanded section of the sealing member back into the cartridge. However, such retracting motion may in turn lead to another built-up of a non-negligible fluid pressure inside the cartridge and as a consequence, a certain amount of the medicament may be supplementally expelled from the cartridge.
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