"Anti-Single-Chain Type Iv Collagen Polypeptide Antibody, Pharmaceutical Drug, Diagnostic, Preventive, Or Therapeutic Drug for Tumour Containing the Antibody" in Patent Application Approval Process
Patent application serial number 888525 has not been assigned to a company or institution.
The following quote was obtained by the news editors from the background information supplied by the inventors: "The present invention relates to a monoclonal antibody that binds to a single-chain type IV collagen polypeptide secreted as a single-chain form of a type IV collagen gene product and suppresses the growth of tumor tissues expressing the single-chain type IV collagen polypeptide. The present invention also relates to a pharmaceutical drug and a diagnostic, preventive, or therapeutic drug for tumor containing the monoclonal antibody.
"Living tissues are composed of cells, which are units of life, and extracellular matrices present around or between the cells. The extracellular matrices are large protein complexes composed mainly of sugar-modified proteins such as collagen, laminin, elastin and proteoglycan. The collagen accounts for approximately 30% of biological proteins and is abundantly found in connective tissues. Also, the collagen constitutes basement membranes at the boundary between epithelial and connective tissues or at the boundary between endothelial and connective tissues. The functions of the extracellular matrices are known to be involved in the control of cell growth and/or differentiation. The interaction between the extracellular matrices and cells has been shown to be important for the development, repair, regeneration, or the like of normal tissues.
"This interaction between the extracellular matrices and cells has also been shown to play an important role in tumor cell growth and angiogenesis during tumor formation. Tumor cells reconstruct an extracellular microenvironment by the repetitive degradation and remodeling of the extracellular matrices. As a result, the growth of the tumor cells or the formation of new blood vessels is promoted to allow tumor tissues to grow. Also, the invasion and/or metastasis of the tumor cells are known to occur due to the degradation of such remodeled extracellular matrices.
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