By a News Reporter-Staff News Editor at Journal of Engineering -- New research on Tissue Engineering is the subject of a report. According to news reporting from Heilongjiang, People's Republic of China, by VerticalNews journalists, research stated, "The extracellular matrix (ECM) is characterized by not only well-preserved scaffolds of organs and vascularized tissues, but also by extremely low immunogenicity during allo- or xeno-implantation. This study aimed to establish a model of a composite microvasculature network scaffold with a small-caliber-dominant vascular pedicle by decellularizing fetal porcine aorta and the conterminous mesentery."
The news correspondents obtained a quote from the research from Harbin Medical University, "The aorta and the conterminous mesenteric vascular system originating from the inferior mesenteric artery were harvested from fetal pigs at late gestation. All of the cellular components were removed by sequential treatment with Triton X-100 and sodium dodecyl sulfate. After the degree of decellularization was assessed, the fetal porcine aorta and mesenteric acellular matrix (FPAMAM) were transplanted into dogs. Gross and histologic examination demonstrated the removal of cellular constituents with preservation of ECM architecture, including macrochannels and microchannels. The residual DNA content in the FPAMAM was less than 2 %. The aorta and microchannels were perfused well, and the fetal porcine aorta had good patency for more than 3 months. The integrity of the FPAMAM provided a scaffold for the reconstruction of a rich vascular network with numerous segmentally radiating branches. Decellularized fetal porcine vascular tissue might be a potential alternative for xenogeneic transplantation based on its optimized properties and low immunogenicity. This journal requires that authors assign a level of evidence to each article."
According to the news reporters, the research concluded: "For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266."
For more information on this research see: The Fetal Porcine Aorta and Mesenteric Acellular Matrix as Small-caliber Tissue Engineering Vessels and Microvasculature Scaffold. Aesthetic Plastic Surgery, 2013;37(4):822-832. Aesthetic Plastic Surgery can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Aesthetic Plastic Surgery - www.springerlink.com/content/0364-216x/)
Our news journalists report that additional information may be obtained by contacting Q.C. Li, Harbin Med Univ, Hosp 2, Div Plast Surg, Harbin, Heilongjiang, People's Republic of China. Additional authors for this research include C.S. Huang, Z.L. Xu, G.F. Liu, Y. Liu, Z.B. Xiao, C.L. Nie, B.Y. Zheng and D.P. Yang.
Keywords for this news article include: Asia, Tissue Engineering, Heilongjiang, People's Republic of China
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC