By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on DNA Research have been published. According to news reporting from Puebla, Mexico, by NewsRx journalists, research stated, "Aggregated states have been alluded to for many DNA minor groove binders but details of the molecule-on-molecule relationship have either been under-reported or ignored. Here we report our findings from ITC and NMR measurements carried out with AIK-18/51, a compound representative of the thiazotropsin class of DNA minor groove binders."
The news correspondents obtained a quote from the research from Autonomous University, "The free aqueous form of AIK-18/51 is compared with that found in its complex with cognate DNA duplex d(CGACTAGTCG)(2). Molecular self-association of AIK-18/51 is consistent with anti-parallel, face-to-face dimer formation, the building block on which the molecule aggregates. This underlying structure is closely allied to the form found in the ligand's DNA complex. NMR chemical shift and diffusion measurements yield a self-association constant K-ass = (61 +/- 19) x 10(3) M-1 for AIK-18/51 that fits with a stepwise self-assembly model and is consistent with ITC data."
According to the news reporters, the research concluded: "The deconstructed energetics of this assembly process are reported with respect to a design strategy for ligand/DNA recognition."
For more information on this research see: Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove. Biophysical Chemistry, 2013;179():1-11. Biophysical Chemistry can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Biophysical Chemistry - www.elsevier.com/wps/product/cws_home/522499)
Our news journalists report that additional information may be obtained by contacting M.V. Salvia, Autonomous Univ Puebla, Dept. of Math & Phys, Fac Chem, Puebla 72570, Mexico. Additional authors for this research include F. Addison, H.Y. Alniss, N.J. Buurma, A.I. Khalaf, S.P. Mackay, N.G. Anthony, C.J. Suckling, M.P. Evstigneev, A.H. Santiago, R.D. Waigh and J.A. Parkinson (see also DNA Research).
Keywords for this news article include: Puebla, Mexico, DNA Research, Nanotechnology, Emerging Technologies, Molecular Recognition, North and Central America
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