By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Biotechnology have been published. According to news reporting originating from Seoul, South Korea, by NewsRx correspondents, research stated, "Despite some controversy, selenomethionine (SeMet)-mediated protection against colorectal cancer (CRC) might be a very promising non-cytotoxic option. However, responsive molecular targets and underlying mechanisms of SeMet-mediated chemoprevention are still unclear."
Our news editors obtained a quote from the research from Kyung Hee University, "Our aim was to discover new targets of SeMet-mediated chemoprevention in CRC using proteomics analysis. We found dietary SeMet supplementation before carcinoma initiation effectively suppressed polyp incidence and dysplastic lesions without any adverse effects. To determine chemopreventive targets of SeMet, we employed two-dimensional gel electrophoresisbased proteomics analysis in CRC mouse model. Pretreatment with SeMet apparently modulated the expression of 30 proteins with functions in major processes like chronic inflammation, oxidative stress and apoptosis as discovered through pathway analysis with Pathway Studio software. We validated four proteins selected from pathway analysis including prohibitin, purine nucleoside phosphorylase, annexin 2 and c-reactive protein by immunohistochemistry. 8-Hydroxy-2'-deoxyguanosine (8-OHdG), a known oxidative stress marker, was decreased by SeMet treatment in CRC mice as seen by immunohistochemistry. Further network analysis was done among these new four validated proteins, 8-OHdG and colorectal cancer."
According to the news editors, the research concluded: "These four proteins found by proteomics analysis might be considered as potential chemopreventive biomarkers of SeMet against colon cancer and can help develop and improve approaches in preventive, therapeutic and prognostic aspects."
For more information on this research see: Discovery of potential targets of selenomethionine-mediated chemoprevention in colorectal carcinoma mouse model using proteomics analysis. Carcinogenesis, 2013;34(7):1575-1584. Carcinogenesis can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Carcinogenesis - carcin.oxfordjournals.org)
The news editors report that additional information may be obtained by contacting M.M. Rahman, Kyung Hee Univ, Sch Med, Inst Biomed Sci IBMS, Dept. of Pharmacol, Seoul 130701, South Korea. Additional authors for this research include Y.R. Seo (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Seoul, Drugs, Oncology, Peptides, Proteins, Carcinoma, Colorectal, Proteomics, South Korea, Amino Acids, Colon Cancer, Chemoprevention, Gastroenterology, Selenomethionine, Cancer Gene Therapy, Organoselenium Compounds
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